中国组织工程研究Issue(2)：342-346,5.DOI:10.3969/j.issn.2095-4344.2013.02.028
骨形态发生蛋白2信号通路与骨发生发育及损伤修复**★
Effect of bone morphogenetic protein 2 signal transduction pathway on osteogenesis, bone development and damage repair
摘要
Abstract
BACKGROUND:Bone morphogenetic proteins play an important role in bone formation, fracture healing and bone induction after bone destruction, and it can be used as a start regulating factor to promote the new bone formation with other signal paths. The regulation of endogenous bone morphogenetic protein 2 can be used as a new target in the future field of bone repair. OBJECTIVE:Through analyzing and summarizing the mechanism of the bone morphogenetic protein signal transduction pathway in endochondral ossification reported from 1988 to now, adult bone growth and development, to explore the role of the bone morphogenetic protein signal pathways in the bone growth and damage repair. METHODS:A computer-based search was performed to search relevant articles about bone morphogenetic protein signaling pathways and its function from VIP and PubMed databases (1998-01/2009-12), respectively by using the key words of“bone morphogenetic protein, endochondral ossification, bone repair”in Chinese and“bone reduction”in English. Literatures irrelevant to research purpose or containing a similar content were eliminated. Final y, 34 articles were chosen for further analysis. RESULTS AND CONCLUSION:Because of its osteoinductive, bone morphogenetic protein signal pathway has become a hot spot in spinal surgery, fracture healing and bone induction after bone destruction. During the bone formation, the bone morphogenetic protein also serves as a start regulating factor to promote the new bone formation with other signal paths. In the bone micro environment, the bone morphogenetic protein and other signal paths that influence bone dynamic balance offer a new target for anabolic therapy that induces the bone formation, which provides a new thought on bone morphogenetic protein control to the formation of new bone fol owing bone repair.关键词
组织构建/组织构建学术探讨/骨形态发生蛋白2/信号通路/骨/损伤修复/软骨内成骨/微环境/骨再生/骨形成/成骨细胞/Sox9/省级基金Key words
tissue construction/academic discussion in tissue construction/bone morphogenetic protein 2/signaling pathway/bone/damage repair/endochondral bone/microenvironment/bone regeneration/bone formation/osteoblasts/Sox9/provincial grants-supported paper分类
医药卫生引用本文复制引用
侯波,王毅,沈宇辉..骨形态发生蛋白2信号通路与骨发生发育及损伤修复**★[J].中国组织工程研究,2013,(2):342-346,5.基金项目
上海市科学自然基金面上项目(10ZR1427800)；上海交通大学医工(理)交叉研究基金项目(YG2011MS10)。 （10ZR1427800）
