中国组织工程研究Issue(2)：353-357,5.DOI:10.3969/j.issn.2095-4344.2013.02.030
最新进展的转基因技术在骨与软骨缺损修复中的应用*★
Latest transgenic technology in bone and cartilage defect repair
摘要
Abstract
BACKGROUND:Tissue engineering technology has made a great progress in bone and cartilage repair, and the introduction of transgenic technology in recent years also has caused widespread concern. OBJECTIVE:To summarize the development of transgenic technology in the repair of bone and cartilage defects in the past 5 years. METHODS:Relevant articles about transgenic technology in bone and cartilage defect which were published from January 2007 to March 2012 were retrieved in CNKI and PubMed with the key words of“gene, therapy, bone, cartilage, defect”in Chinese and English, respectively. Final y, 22 articles that met the inclusive criterion were included. RESULTS AND CONCLUSION:Gene therapy introduces a new treatment concept for bone and cartilage regeneration, which can induce genes into targeted cel s with specific expression. Genes for bone and cartilage defects include bone morphogenetic protein, transforming growth factor, basic fibroblast growth factor, insulin-like growth factor, vascular endothelial growth factor, and Bcl-xl gene. Gene therapy can induce bone and cartilage formation, and provides a new approach for bone and cartilage repairing.关键词
组织构建/组织构建学术探讨/基因/治疗/骨/软骨/缺损/骨形态发生蛋白/转化生长因子/碱性成纤维细胞生长因子/胰岛素样生长因子/血管内皮生长因子/SOX/Bcl-xl/国家自然科学基金分类
医药卫生引用本文复制引用
茹嘉,李强..最新进展的转基因技术在骨与软骨缺损修复中的应用*★[J].中国组织工程研究,2013,(2):353-357,5.基金项目
国家自然科学基金项目(31160199)：腺病毒介导hBMP-2基因转染自体骨髓间充质干细胞治疗股骨头缺血性坏死的研究。 （31160199）
