摘要
Abstract
BACKGROUND:As an open, multi-link and multi-site pathway, wnt signaling pathway plays a very important role in the nervous system. Therefore, it is very important to understand the effects and possible mechanisms for neurogenesis research. OBJECTIVE:To summarize the effect and possible mechanism of wnt signaling pathway in the process of neurogenesis. METHODS:The literatures about the wnt signaling pathway in neurogenesis both at home and abroad were searched, which were published from January 2001 to December 2011, and 19 articles considered to be representative were selected, and then summarized and analyzed. RESULTS AND CONCLUSION:The wnt signaling pathway is involved in embryonic and adult neurogenesis, cortex model and synapse formation. But the role of wnt signaling pathway in these processes is not always consistent. The characteristics and microenvironment of neural stem cel s as wel as different downstream target genes can cause different effects. Meanwhile, the wnt signaling pathway may interact with a variety of signaling pathways, so the final effect on the nervous system is very specific.However, the clear cel ular or molecular mechanisms are stil not very sure.关键词
组织构建/组织构建学术探讨/wnt信号通路/神经干细胞/神经发生/作用机制/综述文献Key words
tissue construction/academic discussion in tissue construction/wnt signal pathway/neural stem cel s/neurogenesis/action mechanism/review literature分类
医药卫生
