中国组织工程研究Issue(3)：452-456,5.DOI:10.3969/j.issn.2095-4344.2013.03.012
鹿脱蛋白松质骨的生物相容性*☆
Biocompatibility of deer deproteinized cancellous bone
摘要
Abstract
BACKGROUND: Antigen-extracted xenogeneic cancel ous bone as a kind of bone implant material has a natural porous structure, plasticity, and certain mechanical strength. OBJECTIVE: To study the biocompatibility of the deer deproteinized cancel ous bone. METHODS: Pyrogen test and acute toxicity test: Fresh deer bone, deproteinized cancel ous bone, and free-dried deproteinized cancel ous bone extracts were injected into the ear vein of rabbits and the abdominal cavity of mice. Hemolysis test: Rabbit mixed blood was added into the fresh deer bone, deproteinized cancel ous bone, and free-dried deproteinized cancel ous bone extracts, sodium carbonate (positive control), and normal saline (negative control). Coagulation test: Fresh deer bone, deproteinized cancel ous bone, and free-dried deproteinized cancel ous bone were placed into normal rabbit mixed blood. Long-term muscle test: Fresh deer bone, deproteinized cancel ous bone, and free-dried deproteinized cancel ous bone were implanted into the thigh muscle pouches of mice. RESULTS AND CONCLUSION: Deer deproteinized cancel ous bone and free-dried deproteinized cancel ous bone had no pyrogen reaction, toxicity, hemolysis and hemopexis reactions, and did not result in rejection reaction after implantation to the thigh muscle pouches of mice. There was a mild abnormality for the fresh deer bone in pyrogen, coagulation, hemolysis and long-term muscle tests without death. These findings indicate that deer deproteinized cancel ous bone and free-dried deproteinized cancel ous bone have good biocompatibility.关键词
生物材料/材料生物相容性/新鲜鹿骨/鹿脱蛋白松质骨/深低温冻干鹿脱蛋白松质骨/生物相容性/溶血实验/凝血实验/急性毒性实验/省级基金Key words
biomaterials/material biocompatibility/fresh deer bone/deer deproteinized cancel ous bone/deer free-dried deproteinized cancel ous bone/biocompatibility/hemolysis tests/coagulation tests/acute toxicity tests/provincial grants-supported paper分类
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刘海鹏,李春,张舵,吴丹凯..鹿脱蛋白松质骨的生物相容性*☆[J].中国组织工程研究,2013,(3):452-456,5.基金项目
吉林省发改委资助课题(20096019)。Supported by：the grant from the Development and Reform Commission of Jilin City, No.20096019* （20096019）
