李盈 1李浪 1苏强 1Kyaw Aung Naing1
作者信息
- 1. 广西医科大学第一附属医院心内科，广西壮族自治区南宁市530021
- 折叠
摘要
Abstract
BACKGROUND: It is stil unknown when drug-eluting stent in-stent restenosis happens, which type of drug-eluting stents should be implanted during percutaneous coronary intervention. OBJECTIVE: To evaluate the efficacy and safety of the same versus different types of drug-eluting stents in treating coronary artery disease patients suffering from in-stent restenosis after first percutaneous coronary intervention using drug-eluting stents. METHODS: PubMed, EMBASE, Google Scholar Research, Cochrane Library and Chinese BioMedical Literature Database on disc were searched for clinical trials about the same and different types of drug-eluting stents in treating coronary artery disease patients suffering from in-stent restenosis after first percutaneous coronary intervention using drug-eluting stents. Then, a meta-analysis was performed. RESULTS AND CONCLUSION: Six articles were enrol ed in the meta-analysis, including 983 cases of in-stent restenosis who received sirolimus-eluting stents or paclitaxel-eluting stents re-implantation fol owing first drug-eluting stent implantation. There were no significant differences between the same and different type of re-implanted drug-eluting stents in al -cause mortality (P=0.31, I2 index (CI) [0.40,2.08]), secondary myocardial infarction (P=0.64, I²=0, OR=2.68, 95% CI[1.00,7.24]), the incidence of in-stent thrombosis (P=0.82, I²=0, OR=2.02, 95% CI[0.37,11.08]), and target lesion revascularization (P=0.63, I²=0, OR=1.15, 95% CI[0.75,1.76]). Based on the obtained statistical results, there was no difference between the efficacy and safety of the same and different types of drug-eluting stents for treatment of in-stent restenosis fol owing the first percutaneous coronary intervention using drug-eluting stents.关键词
生物材料/生物材料循证医学/冠心病/经皮冠状动脉介入治疗/药物洗脱支架/雷帕霉素(西罗莫司)洗脱支架/紫杉醇洗脱支架Key words
biomaterials/evidence-based biomaterials/coronary heart diseases/percutaneous coronary intervention/drug-eluting stents/rapamycin (sirolimus)-eluting stents/paclitaxel-eluting stents分类
医药卫生
