中国组织工程研究Issue(5)：945-950,6.DOI:10.3969/j.issn.2095-4344.2013.05.027
血红素氧化酶1对移植肝脏缺血再灌注损伤的保护**★
Heme oxygenase-1 protects against ischemia-reperfusion injury following liver transplantation
摘要
Abstract
BACKGROUND: During liver transplantation, liver ischemia-reperfusion injury induced primary poor liver graft function has been puzzled the majority of transplant experts and scholars. Heme oxygenase-1 is involved in a variety of diseases and pathological processes, and can protect the tissue and organ through its antioxidant, anti-inflammatory, anti-apoptotic and other mechanisms. OBJECTIVE: To review the protective effect of heme oxygenase-1 against ischemia-reperfusion injury in liver graft. METHODS: A computer-based search of PubMed database 1992-01/2009-12 and China Journal Ful -Text database 2003-01/2010-12 was performed by the first author for the articles on the protective effect of heme oxygenase-1 on ischemia-reperfusion injury in liver graft. The key words were “heme oxygenase-1, ischemia-reperfusion injury, liver graft” in English and Chinese. The repetitive research and Meta-analysis were excluded, and total y retained 34 articles for review. RESULTS AND CONCLUSION: Heme oxygenase-1 may be the most widely distributed gene in animal body, and it had the most important protective effect. Heme oxygenase-1 and its catalytic product compose an important endogenous protection system that is involved in a variety of diseases and pathological processes, and protects the tissue and organ through its antioxidant, anti-inflammatory, anti-apoptotic and other mechanisms with an important clinical application potential. Heme oxygenase-1 has a significant protective effect on ischemia-reperfusion injury in liver graft. Heme oxygenase-1 has a broad clinical application prospect in reducing the ischemia-reperfusion injury and improving the liver graft survival rate if we know how to apply it in clinic by means of transgene, and that is the research direction in future.关键词
器官移植/器官移植综述/血红素氧化酶 1/肝移植/缺血再灌注损伤/转基因/保护/省级基金Key words
organ transplantation/organ transplantation review/heme oxygenase-1/liver transplantation/ischemia-reperfusion injury/transgene/protection/provincial grants-supported paper分类
医药卫生引用本文复制引用
许坚吉,曾仲,陈玺华..血红素氧化酶1对移植肝脏缺血再灌注损伤的保护**★[J].中国组织工程研究,2013,(5):945-950,6.基金项目
云南省自然科学基金资助项目(2007C 137M，2007C0009R)。Supported by：the Natural Science Foundation of Yunnan Province, No.2007C137M*,2007C0009R* （2007C 137M，2007C0009R）
