摘要
Abstract
BACKGROUND: Mesenchymal stem cells have tumor-targeting properties, and can be isolated easily and expand to the numbers required for application, and they can be genetical y manipulated with viral vectors, which suggest the potential of mesenchymal stem cells in the clinical cancer gene therapy. OBJECTIVE: To review the characteristics of mesenchymal stem cells, the tropism of tumor, the relationships between unmodified mesenchymal stem cells and tumor, and the treatment effect of genetical y modified mesenchymal stem cells on tumor. METHODS: A computer-based online search of literatures published between January 2002 to March 2012 related to mesenchymal stem cells and tumor was performed in PubMed database by the first author. The key words were “mesenchymal stem cells, tropism, genetical y modified, tumor, therapy”. The repetitive and unrelated researches were excluded, and final y, 50 articles were included according to inclusion criteria. RESULTS AND CONCLUSION: Mesenchymal stem cells can specifical y migrate to multiple kinds of tumors and their metastases. Some studies have shown that mesenchymal stem cells can promote the growth of tumor and some other studies have shown that they also inhibit the growth of tumor. The mode to modify the mesenchymal stem cells and perform the tumor gene therapy is mainly to carry the suicide gene, apoptosis genes, anti-angiogenic gene, immune-stimulating genes or oncolytic viral vectors. In vitro and in vivo experiments have confirmed the effect of this method on tumor treatment.关键词
干细胞/干细胞综述/间充质干细胞/趋向性/基因修饰/肿瘤/治疗Key words
stem cells/stem cel review/mesenchymal stem cells/tropism/genetical y modified/tumor/therapy分类
医药卫生
