中国组织工程研究Issue(7)：1289-1294,6.DOI:10.3969/j.issn.2095-4344.2013.07.025
组织工程韧带/肌腱构建中相关细胞生长因子的研究与应用*★
Relevant cell growth factors in tissue engineering ligament/tendon construction
摘要
Abstract
BACKGROUND: Construction of tissue engineering ligament/tendon is becoming a hot spot in ligament-reconstructive research recently, which is closely associated with cytokines in vitro or in vivo. OBJECTIVE: To search suitable cytokines for tissue engineering ligament/tendon construction through analyzing and summarizing the current research status of growth factors since 2001, and to explore the action mechanism of these cytokines.METHODS: A computer retrieval was performed in VIP Periodical Ful -Text Database and PubMed database for articles about tissue engineering ligament and relevant cytokines from January 2001 to December 2011 using the key words of “ligament, tendon, tissue engineering, growth factor” in Chinese and English, respectively. Literatures that are repetitive in the content and irrelevant with the objective were excluded. Final y, 33 literatures were involved in further analysis. RESULTS AND CONCLUSION: There are many studies about the growth factors related to tissue engineering ligament/tendon, and most of them can improve the proliferation and differentiation of seedcells into tendon cells, strengthen the biomechanical activity of tissue engineering tendon, and reduce scar formation. Local injection or transgenosis can help the cells to express target proteins efficiently. Application of cel growth factors in tissue engineering ligament/tendon construction is of great significance.关键词
组织构建/组织构建学术探讨/韧带/肌腱/组织工程/生长因子/瘢痕/863 项目Key words
tissue construction/academic discussion of tissue construction/ligament/tendon/tissue engineering/growth factors/scar/the National 863 Program of China分类
医药卫生引用本文复制引用
蔡弢艺,陈雄生,周盛源,王辉,孙延卿,董兴成..组织工程韧带/肌腱构建中相关细胞生长因子的研究与应用*★[J].中国组织工程研究,2013,(7):1289-1294,6.基金项目
国家高技术研究发展计划(863计划)资助(2008AA02Z418)。Supported by：the National High-Tech Research and Development Program of China (863 Program), No.2008AA02Z418* （863计划）
