中国组织工程研究Issue(12)：2205-2209,5.DOI:10.3969/j.issn.2095-4344.2013.12.017
组织工程化神经导管修复外周神经损伤★
Tissue-engineered nerve conduits repair peripheral nerve damage
徐海栋 1赵建宁 1卢俊浩 1陈勇1
作者信息
- 1. 解放军南京军区南京总医院骨科，江苏省南京市210002
- 折叠
摘要
Abstract
BACKGROUND: Theoretical y, nerve conduit technology uses the biological or non-biological materials to prefabricate suitable tubular stent to bridge the nerve ends on both sides. And it can promote the nerve regeneration through neural induction and nutrition under the nerve regeneration microenvironment. OBJECTIVE: To observe the clinical effects of tissue-engineered nerve conduits for repairing peripheral nerve damage. METHODS: Twenty-four patients with old upper extremity nerve damage were selected, and divided into two groups for the treatment according to voluntary principle. The patients in the experimental group were repaired with tissue-engineered nerve conduits, and those in the control group were repaired with autologous surrounding surface sensory nerve transplantation. Al the patients were fol owed-up for 6 months after treatment to observe the repairing functional effect of limb nerve damage.RESULTS AND CONCLUSION: After fol owed-up for 6 months, the limb distal sensory motor function and visual analogue scale scores of the limbs in the two groups were improved compared with those before treatment (P <0.05), and the experimental group showed better effects (P < 0.05); the sensory and motor nerve conduction velocity of the damaged side in the two groups were improved compared with those before treatment (P < 0.05), and there was no significant difference between the two groups. It indicates that tissue-engineered nerve conduit materials can meet the requirements of nerve repair conduit stent and the clinical application is effective.关键词
生物材料/生物材料相容性/神经导管/神经损伤/神经修复/运动神经传导/临床疗效Key words
biomaterials/material biocompatibility/nerve conduit/nerve damage/nerve repair/motor nerve conduction/clinical efficacy分类
医药卫生引用本文复制引用
徐海栋,赵建宁,卢俊浩,陈勇..组织工程化神经导管修复外周神经损伤★[J].中国组织工程研究,2013,(12):2205-2209,5.
