中国组织工程研究Issue(16)：2968-2972,5.DOI:10.3969/j.issn.2095-4344.2013.16.017
脱细胞近交系微型猪肌腱修复兔跟腱缺损*
Acellular tendon of mini-pig inbred-lines is used for Achilles tendon repair in a rabbit model
摘要
Abstract
BACKGROUND:Al ogeneic tendon graft is an ideal method to repair tendon defects. But post-transplantation rejections limit the use of al ogeneic tendons. <br> OBJECTIVE:To investigate the effect of acel ular tendon of Banna mini-pig inbred-lines on repair of rabbit Achiles tendon, and then to evaluate the feasibility and validity of porcine-derived xenogeneic graft. <br> METHODS:Forty Japanese white rabbits were enrol ed to prepare Achil es tendon defect models of the both hind legs, and then were randomly divided into two groups:acel ular porcine tendon group treated with acel ular tendon from Banna mini-pig inbred-lines and autologous tendon group treated with rabbit autologous tendon. End-to-end anastomosis was performed with a 3-0 tendon thread using improved HEMI-KESSLER method. <br> RESULTS AND CONCLUSION:Within 2 weeks post transplantation, there were no significant differences in white blood cel count and C-reactive protein level between the two groups (P>0.05). Local reactions in the two groups after transplantation were few, the wound healed at stage Ⅰ, and flexor ankle function returned to normal. Histological results exhibited no lymphocytic infiltration, but interconnected col agen fibers at tendon suture site. These findings indicate that acel ular tendons from Banna mini-pig inbred-lines can successful y reconstruct defected rabbit Achil es tendon with good histocompatibility and little rejection.关键词
生物材料/细胞外基质材料/脱细胞/猪/肌腱移植物/异种肌腱/自体肌腱/肌腱缺损/兔/其他基金Key words
biomaterials/extracel ular matrix materials/acel ular/porcine/tendon grafts/allogeneic tendons/autologous tendons/tendon defects/rabbits/other grants-supported paper分类
医药卫生引用本文复制引用
靳宪辉,张庆胜,杨建博,刘桂花,魏巍,高春光,林月秋..脱细胞近交系微型猪肌腱修复兔跟腱缺损*[J].中国组织工程研究,2013,(16):2968-2972,5.基金项目
成都军区科研项目(MB07028)。 （MB07028）
