中国组织工程研究Issue(19)：3603-3610,8.DOI:10.3969/j.issn.2095-4344.2013.19.028
骨髓造血干/祖细胞自身抗体与免疫相关性全血细胞减少**★
Autoantibodies on bone marrow hematopoietic stem/progenitor cells and immunorelated pancytopenia
摘要
Abstract
BACKGROUND:mmunorelated pancytopenia involves in multiple clinical disciplines and has been paid more and more attention in recent years. Autoantibodies on bone marrow hematopoietic stem cel s and immune regulation function may be the crux of the problem. OBJECTIVE:To study the progress on the role of bone marrow hematopoietic stem cel-associated antibodies in the pathogenesis of immunorelated pancytopenia. METHODS:A computer retrieval of PubMed, WangFang Med Online and CHKD database was conducted for articles regarding the autoantibodies on bone marrow hematopoietic stem cel s published from March 1992 to March 2012. The keywords were“immunorelated pancytopenia, bone marrow hematopoietic cel s, autoantibody, T helper 17 cel s”. Repetitive articles were excluded, and final y 30 articles were included in result analysis. RESULTS AND CONCLUSION:The production of autoantibodies on bone marrow hematopoietic cel s is due to the imbalance in T lymphocyte regulation resulting in abnormal quantity and function of B lymphocyte and its subset. They destroyed or inhibited the differentiation and maturation of bone marrow hematopoietic cel s, leading to a reduction of peripheral blood cel s eventual y. The increasing number of T helper 17 cel s and the hyperfunction of T helper 17 cel s may be associated with the production of autoantibodies in patients with immunorelated pancytopenia, which is an important factor for the pathogenesis of immunorelated pancytopenia.关键词
干细胞/干细胞学术探讨/免疫相关性全血细胞减少症/骨髓造血干/祖细胞/骨髓造血细胞/T辅助细胞17/自身抗体/白细胞介素17/T淋巴细胞调控/IgG/IgM/流式细胞术双标法/省级基金分类
医药卫生引用本文复制引用
董婷,李正发,欧阳红梅,沈晓梅..骨髓造血干/祖细胞自身抗体与免疫相关性全血细胞减少**★[J].中国组织工程研究,2013,(19):3603-3610,8.基金项目
云南省内设研究机构专项基金资助项目(2010NC002)；云南省教育厅科学研究基金资助项目(2012J092)。 （2010NC002）
