中国组织工程研究Issue(24)：4539-4544,6.DOI:10.3969/j.issn.2095-4344.2013.24.024
脊髓发育和损伤修复过程中巢蛋白的作用及机制****
Effect and mechanism of nestin in the spinal cord development and injury repair process
摘要
Abstract
BACKGROUND: As a specific marker of neurons, expression activity of Nestin to a certain extent reflects the evolution law of spinal cord nerve cel s’s proliferation, differentiation and migration. OBJECTIVE: To review the molecular structure, biological function, and expression and distribution law of Nestin in spinal cord development and damage repair, then to provide previous research foundation in the transplantation of neural stem cel s after spinal cord injury. METHODS: VIP and Wanfang databases (1990/2012) were retrieved by computer with the key words of “spinal cord, Nestin” in Chinese. At the same time, PubMed, Springer and e-book (ful text) databases (1990/2012) were retrieved with the key words of “spinal cord, Nestin” in English. Total y 343 articles were retrieved, and final y 35 articles were included. RESULTS AND CONCLUSION: As a specific marker of neural stem cel s, Nestin at embryo stage shows a space-time expression that has a inverse relationship with the mature degree of neural precursor cel s, namely with neural cel differentiation and growth continued to mature, Nestin expression strength would gradual y abate, and even disappear. And in spinal cord injury pathological situations, Nestin expression strength and quantity in damaged tissue zone also reflect the repair ability of damaged spinal cord tissues. So during the development of spinal cord tissues, Nestin expression strength, quantity and distribution is now an important index for judging the development of spinal cord nerve cel s, which can provide significant preliminary basis for research work for clinical treatment of spinal cord injury.关键词
组织构建/组织构建综述/脊髓/巢蛋白/脊髓损伤/发育/损伤/修复/神经元/脊髓神经细胞/标记物/国家自然科学基金Key words
tissue construction/tissue construction review/spinal cord/nestin/spinal cord injury/development/injury/repair/neurons/spinal cord neurons/markers/National Natural Science Foundation of China分类
医药卫生引用本文复制引用
王诗韵,张若煜,刘学红..脊髓发育和损伤修复过程中巢蛋白的作用及机制****[J].中国组织工程研究,2013,(24):4539-4544,6.基金项目
浙江省大学生科技活动计划“新苗人才计划”(2011R426020)，绍兴市科技计划项目(2009A33025)，浙江省科技计划项目(2012C33066)，国家自然科学基金(81100241)。 （2011R426020）
