中国组织工程研究Issue(27)：5041-5047,7.DOI:10.3969/j.issn.2095-4344.2013.27.015
异基因外周血干细胞移植后的心膈角髓肉瘤★
Myeliod sarcoma in cardio-phrenic angle after allogeneic peripheral blood stem cell transplantation
何易 1李旭东 1王东宁 1胡元 1王文文 1刘加军 1林东军 1黄仁魏1
作者信息
- 1. 中山大学血液病研究所，中山大学附属第三医院血液内科，广东省广州市 510630
- 折叠
摘要
Abstract
BACKGROUND: Al ogeneic hematopoietic stem cel transplantation is the main method to cure leukemia, but the patients receiving al ogeneic hematopoietic stem cel transplantation stil have to face the risk of recurrence. Myeloid sarcoma is a rare extramedul ary relapse mode with worse clinical outcomes, so it is necessary to understand the characteristics of myeloid sarcoma and relative treatment methods. OBJECTIVE: To analyze the clinical characteristics and treatment methods of myeliod sarcomas in cardio-phrenic angle after al ogeneic peripheral blood stem cel transplantation. METHODS: One case was diagnosed as single myeloid sacoma in the cardio-phrenic angle after al ogeneic peripheral blood stem cel transplantation. The patient underwent surgical resection of the mass, chemotherapy and radiotherapy. The clinical effect, complications and survival situation were observed. RESULTS AND CONCLUSION: The patient suffered from bacteremia, fungal pneumonia and even life-threatening sepsis shock during two courses chemotherapies. Then, the patient received radiotherapy for mediastinum and the myeloid sacoma never relapsed. However, the patient suffered central nervous system leukemia after free of the disease for 25 months. Myeliod sarcoma after al ogeneic hematopoietic stem cel transplantation is rare and its manifestation is changeful. The diagnosis mainly depends on histopathology and immunohistochemistry. Surgery, chemotherapy, radiotherapy, second transplantation and molecular targeted drugs are the choices of treatment strategy. However, the optimal treatment strategy for individual patients remains to be determined.关键词
干细胞/干细胞移植/急性髓系白血病/异基因干细胞移植/髓肉瘤/心膈角/化疗/放疗/干细胞图片文章Key words
stem cells/stem cel transplantation/acute myeloid leukemia/al ogeneic stem cel transplantation/myeliod sarcoma/cardio-phrenic angle/chemotherapy/radiotherapy/stem cel photogranphs-supporting paper分类
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何易,李旭东,王东宁,胡元,王文文,刘加军,林东军,黄仁魏..异基因外周血干细胞移植后的心膈角髓肉瘤★[J].中国组织工程研究,2013,(27):5041-5047,7.
