中国组织工程研究Issue(28)：5171-5176,6.DOI:10.3969/j.issn.2095-4344.2013.28.012
淫羊藿苷可抑制正畸致牙根的吸收★
Icariin inhibits orthodontically induced inflammatory root resorption
周艳妮 1曹宝成 1蒋小龙 2曹帅1
作者信息
- 1. 兰州大学口腔医学院正畸科，甘肃省兰州市 730000
- 2. 甘谷县中医院，甘肃省甘谷县 741200
- 折叠
摘要
Abstract
BACKGROUND: Icari n as one of the main components of Epimedium has an inhibitory effect on osteoclasts.. OBJECTIVE: To further investigate the influence of icariin on the root absorption of the maxil ary first molar at mesial part during orthodontic treatment in rats. METHODS: Orthodontic root resorption models were established in the left maxil a of rats. Local injection of 200 mg/kg icari n (icari n group) or normal saline (positive control group) was administrated into the left first molar buccal periosteum. The right maxil a of rats served as negative control group that was treated with neither appliance nor drug injection. The mesial distance between bilateral first molars and the contralateral maxil ary incisor was measured before and after the appliance was placed. Mesial surface of the mesial root of bilateral maxil ary first molars was observed using scanning electron microscope. RESULTS AND CONCLUSION: Mesial movement of the maxil ary molars in the icari n group was significantly less than that in the positive control group (P < 0.05). Under the scanning electron microscope, smal absorption lacunae were scattered in the icari n group, while the positive control group showed a large amount of absorption lacunae and they were interconnected into a sheet, showing a stark contrast with the smooth root surface of the negative control group. It is indicated that icari n can inhibit root resorption caused by orthodontic treatment, while reducing the amount of mesial movement of the molar under corrective force.关键词
组织构建/口腔组织构建/淫羊藿/淫羊藿苷/正畸致牙根吸收/正畸/牙根吸收/上颌/矫治器/扫描电镜/移动量/第1磨牙Key words
tissue construction/oral tissue construction/Epimedium/icariin/orthodontic root resorption/orthodontics/root resorption/maxil ary/appliance/scanning electron microscopy/movement amount/the first molar分类
医药卫生引用本文复制引用
周艳妮,曹宝成,蒋小龙,曹帅..淫羊藿苷可抑制正畸致牙根的吸收★[J].中国组织工程研究,2013,(28):5171-5176,6.
