中国组织工程研究Issue(29)：5387-5394,8.DOI:10.3969/j.issn.2095-4344.2013.29.019
新型组织工程血管材料：静电纺复合纳米纤维小口径管状支架★
A new vascular tissue engineering material:Electrospun small-diameter nanofibous scaffolds
吴桐 1黄晨 1莫秀梅2
作者信息
- 1. 生物材料与组织工程实验室，化学化工与生物工程学院，东华大学，上海市 201620
- 2. 纺织学院，东华大学，上海市 201620
- 折叠
摘要
Abstract
BACKGROUND:Due to the much higher requirement of biocompatibility and anticoagulant of smal-diameter vascular grafts than those of large-diameter ones, in situ blood vessel regeneration occurs as a new research direction. OBJECTIVE:To summarize the recent research development of electrospun smal-diameter scaffolds and to explore the application of in situ blood vessel regeneration and the development tendency. METHODS:The first author retrieved China National Knowledge Infrastructure database, Wanfang data and ISI Web of Knowledge foreign database to retrieve literatures addressing the fabrication of electrospun smal-diameter nanofibrous vascular grafts, surface modification and mimicking extracel ular matrix, as wel as the evaluation of biocompatibility and security after grafting. RESULTS AND CONCLUSION:Electrospun smal-diameter nanofibrous vascular grafts have emerged as promising candidates in vascular tissue engineering. By using both natural and synthetic polymers, the scaffolds can achieve a good balance between mechanical property and biocompatibility. Meanwhile, the fabrication of multi-layered vascular scaffolds, functional surface modification and mimicking extracel ular matrix structural y and functional y are now becoming attractive research directions. However, at current stage, electrospun vascular scaffolds used clinical y are basical y formed by synthetic materials, which have limited biocompatibility and anticoagulant activity. In this case, more efforts should be paid to find an optimal ratio between natural and synthetic materials for the improvement of biocompatibility and anticoagulant ability of smal-diameter vascular grafts.关键词
生物材料/生物材料综述/血管组织工程/静电纺丝/小口径管状支架/原位再生/纳米纤维/聚合物/天然材料/合成材料生物材料Key words
biomaterials/biomaterial review/vascular tissue engineering/electrospinning/smal-diameter tubular scaffold/in situ regeneration/nanofibers/polymer/natural materials/synthetic materials分类
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吴桐,黄晨,莫秀梅..新型组织工程血管材料：静电纺复合纳米纤维小口径管状支架★[J].中国组织工程研究,2013,(29):5387-5394,8.
