中国组织工程研究Issue(34)：6097-6102,6.DOI:10.3969/j.issn.2095-4344.2013.34.006
重组牛碱性成纤维细胞生长因子凝胶预防拔牙后干槽症
Recombinant bovine basic fibroblast growth factor gel prevents dry socket syndrome after toothextraction
薛令法 1许尧祥 1岳金 1王双义 1肖文林 1张春阳1
作者信息
- 1. 青岛大学医学院附属医院黄岛分院口腔颌面外科，山东省青岛市 266555
- 折叠
摘要
Abstract
BACKGROUND:Recombinant bovine basic fibroblast growth factor is a manifold effect cytokine which can promote angiogenesis, wound healing, tissue repair and bone regeneration. Recombinant bovine basic fibroblast growth factor with good histocompatibility is easy to operate and has been widely used in oral and maxil ary surgery. <br> OBJECTIVE:To evaluate the effect of recombinant bovine basic fibroblast growth factor against dry socket syndrome after tooth extraction. <br> METHODS:A total of 160 patients who had been extracted mandibular third molar were selected and randomly divided into two groups. In the experimental group, recombinant bovine basic fibroblast growth factor was put into the sockets after mandibular third molars were extracted, while in the control group, we let the wounds to be healed natural y without any materials. The incidence of dry socket syndrome was observed and compared between two groups at 3 days, 5 days and 1 week after tooth extraction. <br> RESULTS AND CONCLUSION:One patient had dry socket after operation in the experimental group, and the incidence was 1.25%. In the control group, 10 patients suffered from dry socket, and the incidence was 12.5%. There was a significant difference in the incidence of dry socket between the two groups (P<0.01). There was visible granulation tissue within the tooth socket after tooth extraction in the experimental group, and extraction sockets narrowed and were fil ed with granulation tissues, which was 1-2 days earlier than the control group. No al ergies, tissue hyperplasia and other local and systemic reactions occurred in patients receiving implantation of recombinant bovine basic fibroblast growth factor gel. These findings indicate that local implantation of recombinant bovine basic fibroblast growth factor gel after mandibular tooth extractions can speed up the healing of dental extraction wounds.关键词
生物材料/组织工程口腔材料/碱性成纤维细胞生长因子/干槽症/阻生牙/凝胶/生物活性因子/牙拔除/过敏/组织增生/并发症Key words
biomaterials/tissue-engineered oral materials/basic fibroblast growth factor/dry socket/impacted teeth/gel/bioactive factors/tooth extraction/al ergies/tissue hyperplasia/complications分类
医药卫生引用本文复制引用
薛令法,许尧祥,岳金,王双义,肖文林,张春阳..重组牛碱性成纤维细胞生长因子凝胶预防拔牙后干槽症[J].中国组织工程研究,2013,(34):6097-6102,6.
