中国组织工程研究Issue(35)：6327-6332,6.DOI:10.3969/j.issn.2095-4344.2013.35.017
骨髓间充质干细胞治疗股骨头坏死的评价*
Evaluation of bone marrow mesenchymal stem cells for the treatment of osteonecrosis of femoral head
摘要
Abstract
BACKGROUND:There are various methods for the treatment of osteonecrosis of femoral head, but there is no satisfactory method to promote the repair of osteonecrosis of femoral head. In recent years, bone marrow <br> mesenchymal stem cel transplantation for the treatment of osteonecrosis of femoral head has achieved certain effect. <br> OBJECTIVE:To review the application progress and problems of bone marrow mesenchymal stem cel transplantation for the treatment of osteonecrosis of femoral head. <br> METHODS:A computer-based online search was performed in PubMed database, Wanfang database and CNKI database for the related articles from 1999 to 2012. The articles on the isolation, culture, differentiation, labeling and in vivo tracing of bone marrow mesenchymal stem cel s were selected, as wel as the basic and clinical <br> researches on bone marrow mesenchymal stem cel transplantation for the treatment of osteonecrosis of femoral head. A total of 39 articles were included for review. <br> RESUTLS AND CONCLUSION:At present, the method for the isolation of bone marrow mesenchymal stem cel s includes adherence screening method, density gradient centrifugation, flow cytometry separation and magnetic activated cel sorting method;the commonly used method for cel labeling and tracing includes isotope tracing method, antigen labeling method, antigen labeling, fluorescent labeling and MRI contrast enhancer labeling <br> method. The method for the treatment of osteonecrosis of femoral head with bone marrow mesenchymal stem cel s includes pith dril ing decompression combined with bone marrow mesenchymal stem cel injection and <br> transplantation, intervention plus bone marrow mesenchymal stem cel transplantation, gene transfection combined with bone marrow mesenchymal stem cel transplantation and tissue engineering technology of bone marrow mesenchymal stem cel s. Although, the research on the bone marrow mesenchymal stem cel transplantation for the treatment of <br> osteonecrosis of femoral head has achieved great progress, there are stil problems needed to be further solved.关键词
骨关节植入物/骨与关节综述/骨髓间充质干细胞/股骨头坏死/细胞培养/细胞示踪/细胞分化/省级基金Key words
bone and joint implants/review of bone and joint/bone marrow mesenchymal stem cel s/osteonecrosis of femoral head/cel culture/cel tracing/cel differentiation/provincial grants-supported paper分类
医药卫生引用本文复制引用
李瑞琦,张国平,任立中,李亚丽,吕亚军..骨髓间充质干细胞治疗股骨头坏死的评价*[J].中国组织工程研究,2013,(35):6327-6332,6.基金项目
Key Project of Hebei Medical Science Research, No.20120286* （）
