中国组织工程研究Issue(38)：6092-6097,6.DOI:10.3969/j.issn.2095-4344.2015.38.005
正畸应力刺激下纯钛微种植体周围炎模型及骨改建
Histological changes of pure titanium micro-implant under inflammatory stimulation and orthodontic force as well as bone remodeling
摘要
Abstract
BACKGROUND:Implant stability is mainly influenced by peri-implant inflammatory stimulation. <br> OBJECTIVE:To build a beagle model of peri-implantitis under orthodontic force and to observe the bone remodeling of the Beagle dog model. <br> METHODS: Micro-implants were randomly implanted into the maxilary interradicular region at the center of the mesial and distal roots of bilateral P2, P3, P4 and M1 of Beagle dogs. One side served as a loaded micro-implant with peri-implantitis under 100 g of orthodontic force at 1, 2, 3, 4 weeks of peri-implantitis, and the force lasted for 1 month. After that, the animals were kiled to prepare specimens with micro-implants. Bone-to-implant contacts were calculated and histological changes of the bone interface under continuous orthodontic force at different stages of peri-implantitis were observed under light microscope. <br> RESULTS AND CONCLUSION:There were a large number of inflammatory cels after micro-implants were implanted with silk thread ligation to the cervical part. Over time, inflammatory cels were gradualy diffused to the tip of micro-implant, and there were a great quantity of colagenous fibers, osteocytes and active bone remodeling. When the inflammation was diffused to the tip of micro-implant after 2 weeks of peri-implantitis, woven bones composed of newly formed trabeculae appeared, and imflammatory cels dispersed. The medulary cavity was irregular after colagen fibrils absorption, and there were 3-4 layers of osteoblasts in the bone lacunae, with active bone formation. These findings indicate that the Beagle model of pure titanium peri-implantitis under orthodontic force was successfuly built in the experiment, and bone formation became active at 2 weeks after modeling.关键词
生物材料/口腔生物材料/正畸应力/比格犬/微种植体/动物模型/种植体周围炎/正畸支抗/甲苯胺蓝染色/亚甲基蓝-ViGi 染色/硬组织切片/成骨细胞/国家自然科学基金分类
医药卫生引用本文复制引用
张晓歌,唐甜,赵志河,丁寅..正畸应力刺激下纯钛微种植体周围炎模型及骨改建[J].中国组织工程研究,2015,(38):6092-6097,6.基金项目
中国博士后科学基金(2013M532159)；国家自然科学青年基金(10902075)Funding：China Postdoctoral Science Foundation, No.2013M532159 （2013M532159）
the National Natural Science Foundation of China, No.10902075 （）
