中国组织工程研究Issue(41)：6671-6676,6.DOI:10.3969/j.issn.2095-4344.2015.41.020
自体骨髓干细胞移植治疗动脉硬化闭塞症：7年结局评价
Autologous bone marrow stem cell transplantation for arteriosclerosis obliterans：a 7-year outcome evaluation
摘要
Abstract
BACKGROUND:With the development of surgical techniques and endovascular treatment techniques, the therapeutic efficacy on arteriosclerosis obliterans of the lower limbs has been improved greatly. As the long-term prognosis is stil not clear, how to treat arteriosclerosis obliterans of the lower limbs is stil a problem for vascular surgery. OBJECTIVE:To observe the long-term clinical efficacy of autologous bone marrow stem cel transplantation in the treatment of arteriosclerosis obliterans of the lower limbs. METHODS:Thirty-nine patients with arteriosclerosis obliterans who had undergone autologous bone marrow mesenchymal stem cels (totaly 56 times of cel transplantation) from September 2007 to July 2013 were enroled in this study. As of February 2015, the folow-up time was 7.5 years. After treatment, regular telephone folow-up about limb pain, cold sensation, intermittent claudication distance, resting ankle-brachial index and limb ulcer size and depth was done annualy; at 1 year after treatment, limb arteriography and venous blood gas analysis were reviewed. RESULTS AND CONCLUSION: Of the enroled 39 patients, 4 patients were subjected to amputation because of poor efficacy, 2 patients died of acute myocardial infarction, and 2 patients died of not timely amputation. There were 31 patients who had been folowed up for over 3 years. After treatment, the resting ankle-brachial index and limb ulcer size and depth limb pain were both improved significantly. There were significant differences in 1-year limb blood oxygen partial pressure and oxygen saturation before and after treatment, and the postoperative number of capilaries also increased significantly. These findings indicate that autologous bone marrow stem cel transplantation is a safe treatment for arteriosclerosis obliterans of the lower limbs with better and stable long-term curative effects. This method is a good choice for patients who have poor blood vessels and poor efficacy of traditional methods.关键词
干细胞/移植/下肢动脉硬化闭塞症/自体骨髓干细胞/踝肱指数/新疆维吾尔自治区自然科学基金Key words
Myeloid Progenitor Cels/Stem Cel Transplantation/Arteriosclerosis Obliterans/Tissue Engineering分类
医药卫生引用本文复制引用
白超,田野,罗军..自体骨髓干细胞移植治疗动脉硬化闭塞症：7年结局评价[J].中国组织工程研究,2015,(41):6671-6676,6.基金项目
新疆维吾尔自治区自然科学基金资助项目(2010211A48)Funding:the Natural Science Foundation of Xinjiang Uygur Autonomous Region, No.2010211A48 （2010211A48）
