中国组织工程研究Issue(43)：7010-7016,7.DOI:10.3969/j.issn.2095-4344.2015.43.023
结构特征对磷酸钙陶瓷骨诱导活性的影响
Structural properties influence the osteoinduction of calcium phosphate ceramics
摘要
Abstract
BACKGROUND:Currently, the mechanism by which calcium phosphate ceramics induces osteogenesis is not fuly understood, and many scholars have tried to expound the mechanism from the perspective of the structural properties. OBJECTIVE:To review how the structural properties of calcium phosphate ceramics affect their osteoinductive activity. METHODS: The PubMed database and Google academic database (1997-01/2015-03) were searched to retrieve the related articles about the structural properties of calcium phosphate ceramics affecting their osteoinductive activity. After the articles with outdated reviews or repetitive contents were ruled out, 60 articles were suitable for further analysis and review. RESULTS AND CONCLUSION:The structural properties of calcium phosphate ceramics are displayed by macrostructure, such as macropores, holes, pipes and space between particles, and microstructure, such as micropore, particle size, surface roughness, specific surface area. Each parameter of the structural properties affects the bioactivities of calcium phosphate ceramics in some way, which renders their abilities of inducing osteogenesis to arise from nothing or change from weakly to strongly. Apart from structure design, physical and chemical properties of calcium phosphate ceramics wil also affect its biological activityin vivo. Therefore, the physicochemical properties of calcium phosphate ceramics should be considered in the structure design in order to achieve an optimal osteoinductive activity.关键词
生物材料/骨生物材料/磷酸钙陶瓷/骨诱导活性/宏孔/孔隙率/贯通性/表面粗糙/国家自然科学基金/组织构建分类
医药卫生引用本文复制引用
孟磊,甄平,梁晓燕,曹雪飞..结构特征对磷酸钙陶瓷骨诱导活性的影响[J].中国组织工程研究,2015,(43):7010-7016,7.基金项目
国家自然科学基金面上项目(81371983)多孔β-TCP 负载PLGA 抗结核药物缓释微球的构建及其抗结核成骨作用研究 （81371983）
