现代医药卫生Issue(20)：3062-3064,3066,4.DOI:10.3969/j.issn.1009-5519.2015.20.006
血浆置换及静脉注射免疫球蛋白治疗格林巴利综合征临床研究
Clinical study on plasmapheresis and intravenous immunoglobulin in treating Guillain-Barre syndrome
王丹 1郭珍立 1任敏 2曾可斌2
作者信息
- 1. 湖北省新华医院神经内科，武汉430015
- 2. 重庆医科大学附属第一医院神经内科，重庆400016
- 折叠
摘要
Abstract
Objective To compare the clinical effects of small dose of plasma exchange (SVP),high-dose plasma ex-change (LVP) and intravenous immunoglobulin(IVIG) in treating Guillain-Barre syndrome(GBS). Methods 75 GBS inpatients in the First Affiliated Hospital of Chongqing Medical University from June 2008 to June 2014 were randomly assigned to the SVP group(41 cases),LVP group(8 cases) and IVIG group(26 cases) according to the voluntary choice and plasma sources. Then the clinical data,efficacy and adverse reactions in 3 groups were analyzed. Results The total effective rates in the SVP group,LVP group and IVIG group were 90.2%,87.5%and 92.3%respectively,the differences were not statistically significant(χ2=0.91,P=0.186),but the SVP group had longer hospitalization duration and the LVP group had higher occurrence rate of adverse reactions , the hospitalization duration and the occurrence rate of adverse reactions had statistical difference among 3 groups (P<0.05). Con-clusion SVP,LVP and IVIG all are the effective way for treating GBS at present. Early treatment can significantly improve the prognosis. The three kinds of therapy have no significant difference in the curative effects.关键词
血浆置换/免疫球蛋白类/输注,静脉内/格林-巴利综合征/自身免疫疾病/多发性神经根神经病Key words
Plasma exchange/Immunoglobulins/Infusions,intravenous/Guillain-Barre syndrome/Autoim-mune diseases/Polyradiculoneuropathy引用本文复制引用
王丹,郭珍立,任敏,曾可斌..血浆置换及静脉注射免疫球蛋白治疗格林巴利综合征临床研究[J].现代医药卫生,2015,(20):3062-3064,3066,4.
