刑事技术Issue(5)：368-372,5.DOI:10.16467/j.1008-3650.2015.05.005
线粒体全基因组测序在法医学中的应用
Whole Genome Sequencing of Mitochondria and Its Application in Forensic Science
摘要
Abstract
Compared to nuclear DNA, mitochondrial DNA (mtDNA) has many unique characters, and plays an important role in some specific cases. Traditional analysis of mitochondrial DNA is to partially sequence the high variant regions of mitochondrial genome. Presently, with the development of techniques in molecular biology and bioinformatics, the next generation sequencing (NGS) enables the mitochondrial DNA analysis into whole genome sequencing which provides more comprehensive information and raises the power of discrimination. Furthermore, whole genome analysis of mitochondrial DNA will give extra information assisting in sample source inferring, haplogroup detecting, diseases testing and among others. In this paper, we will review the classic and the newly emerging mitochondrial sequencing strategies including their advantages and disadvantages. Besides, we will give a brief introduction to the new applications of mitochondrial genome sequencing in forensic genetics, mitochondria diseases and aging research, and show the novel findings along with these practices. Finally, we will discuss the prospect of forensic application of mitochondrial whole genome sequencing, as well as the benefits and potential problems it may bring together.关键词
法医遗传学/线粒体 DNA/二代测序Key words
forensic genetics/mitochondrial DNA/next generation sequencing分类
社会科学引用本文复制引用
姚岚,李万水,胡兰,徐珍..线粒体全基因组测序在法医学中的应用[J].刑事技术,2015,(5):368-372,5.基金项目
公安部科技强警基础工作专项项目 （）
