新医学Issue(9)：620-624,5.DOI:10.3969/g.issn.0253-9802.2015.09.013
新辅助化学治疗在原发性小细胞食管癌综合治疗中的价值
Significance of neoadjuvant chemotherapy in comprehensive treatment of small cell esophageal cancer
郝曙光 1侯夏宝 1刘平1
作者信息
- 1. 453000 新乡，河南新乡市中心医院肿瘤外科胸瘤一区
- 折叠
摘要
Abstract
Objective To evaluate the curative effect of neoadjuvant chemotherapy in the comprehen-sive treatment of small cell esophageal cancer.Methods Clinical data of 53 cases of small cell esophageal cancer were retrospectively analyzed.Among them,29 patients underwent neoadjuvant chemotherapy combined with surgical treatment (observation group)and 24 received surgery alone (control group).Kaplan-Meier method was used for univariate analysis and Cox regression was adopted to conduct multivariate analysis.Re-sults The median survival time of 53 cases was 24 months (3-51 months).Postoperative positive rate of lymph node in the observation group was significantly lower compared with that in the control group (24.1%vs.75.0%,P <0.05).The 3-year survival rate in the observation group was significantly higher than that in the control group (33.3% vs.4.5%,P <0.05).Univariate analysis revealed that tumor site and size,the presence of positive lymph nodes and different interventions were significantly correlated with 3-year survival rate (P =0.048,0.018,0.030 and 0.039).Multivariate analysis indicated that tumor site and size,the presence of posieive lymph nodes and different treatment was an independent prognostic factor of patients’sur-vival.Conclusion Neoadjuvant chemotherapy plays a pivotal role in the comprehensive treatment of small cell esophageal cancer and serves as a vital influencing factor of clinical prognosis.关键词
小细胞食管癌/新辅助化学治疗/预后Key words
Small cell esophageal cancer/Neoadjuvant chemotherapy/Prognosis引用本文复制引用
郝曙光,侯夏宝,刘平..新辅助化学治疗在原发性小细胞食管癌综合治疗中的价值[J].新医学,2015,(9):620-624,5.
