烟草科技2015，Vol.48Issue(9)：50-55,6.DOI:10.16135/j.issn1002-0861.20150909
气相色谱-串联质谱法同时检测卷烟主流烟气中的苯并[a]芘和NNK
Simultaneous Determination of Benzo[a]pyrene and NNK in Mainstream Cigarette Smoke by Gas Chromatography-Tandem Mass Spectrometry
陈晓水 1汤晓东 1张博 1蒋佳磊 1朱书秀 1陆明华1
作者信息
- 1. 浙江中烟工业有限责任公司技术中心,杭州市西湖区转塘镇科海路118号 310024
- 折叠
摘要
Abstract
A method for simultaneously determining the benzo[a]pyrene (BaP) and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in mainstream cigarette smoke by gas chromatography-tandem mass spectrometry (GC-MS/MS) was developed. The total particulate matter of mainstream cigarette smoke was collected on a Cambridge filter pad, then extracted with toluene by oscillation. The extract was cleaned up by dispersive solid phase extraction (d-SPE), concentrated by nitrogen gas flow, separated by DB-35MS column, and determined by internal standard method under multi-reaction monitoring (MRM) mode. The results showed that: 1) The limits of quantitations (LOQs), recoveries and relative standard deviations (RSDs) of NNK and BaP were 0.36 and 0.29 ng/cig, 78.8%-95.5% and 101.6%-106.6%, 2.3%-15.4% and 2.9%-14.4%, respectively. 2) Comparing with the standard method, the developed method was simpler in pretreatment, and capable of simultaneous determination of the two target analytes. 3) The data of 27 cigarette samples determined by the developed method well agreed with those by the standard method, there was no significant difference. The method is simple, accurate and suitable for the simultaneous determination of NNK and BaP in mainstream cigarette smoke.关键词
卷烟/苯并[a]芘(BaP)/4-(N-甲基-N-亚硝氨基)-1-(3-吡啶基)-1-丁酮(NNK)/气相色谱-串联质谱(GC-MS/MS)Key words
Cigarette/Benzo[a]pyrene (BaP)/4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK)/Gas chromatography-tandem mass spectrometry (GC-MS/MS)分类
轻工纺织引用本文复制引用
陈晓水,汤晓东,张博,蒋佳磊,朱书秀,陆明华..气相色谱-串联质谱法同时检测卷烟主流烟气中的苯并[a]芘和NNK[J].烟草科技,2015,48(9):50-55,6.
