摘要
Abstract
Objective To study the prognosis of intravenous thrombolytic therapy on hemorrhagic transformation of acute cerebral infarction combined with cerebral microbleeds. Methods 86 cases of patients with acute cerebral infarction combined with cerebral microbleeds admitted to our hospital from February 2012 to February 2015 were selected and randomly divided into research group and control group, with 43 cases in each group. The control group was treated with placebo, the research group was treated with intravenous thrombolysis. All patients were followed up for 3 months. The nerve function defect was evaluated by US national institutes of health stroke scale (NIHSS), the long-term prognosis was evaluated by modified Rankin scale. The hemorrhagic transformation rate, mortality, mRS score 3 months after treatment, NIHSS score before and after the treatment were compared between two groups. Results The hemorrhagic transformation rate of research group was 20.9%, higher than 2.3%of control group, with statistical difference (P<0.05);the mortality of two groups had no statistical difference (9.3%vs 7.0%, P>0.05). The NIHSS score after 24 h, 14 d of the treatment and mRS score after 3 months of the treatment in research group were lower than those of control group, with statistically significant difference (P <0.05). Conclusions Intravenous thrombolysis in the treatment of acute cerebral infarction combined with cerebral microbleeds will increase the risk of hemorrhagic transformation, but can effectively improve the nerve function defect and long-term prognosis, without increasing total mortality, which is worthy of clinical promotion.关键词
静脉溶栓/脑微出血/急性脑梗死/出血性转化Key words
Intravenous thrombolysis/Cerebral microbleeds/Acute cerebral infarction/Hemorrhagic transformation分类
医药卫生
