摘要
Abstract
Objective To explore the effects of aspirin combined with different doses of lipitor on cerebral blood flow and atherosclerotic plaque of patients with cerebral infarction. Methods The clinical data of 168 patients with cerebral infarction admitted to our hospital from June 2013 to December 2014 were analyzed retrospectively. All patients were divided into four groups according to the doses of lipitor:low dose group (10 mg/d), middle dose group (20 mg/d), high dose group (40 mg/d) and control group (without use of lipitor). In addition, all patients were given aspirin for therapy. Transcranial Doppler ultrasound was used to detect the average velocity of cerebral artery blood flow and pulsatility index of cerebral artery, and the carotid ultrasound was used to detect the carotid intima-media thickness and atherosclerotic plaque area. Results Before therapy, no statistical difference was found in the average velocity of cerebral artery blood flow, pulsatility index of cerebral artery, carotid intima-media thickness and atherosclerotic plaque area among 4 groups (P>0.05). After therapy, the average velocity of cerebral artery blood flow of the control group was significantly lower than the other three groups (P<0.05), and the increment of blood flow velocity increased with the increasing doses of lipitor. After therapy, the pulsatility index of cerebral artery of control group was significantly higher than the other three groups (P<0.05), and the pulsatility index of cerebral artery decreased with the increasing doses of lipitor . After therapy, the carotid intima-media thickness and atherosclerotic plaque area of the control group were significantly higher than those of the other three groups (P<0.05), and the values of both indicators decreased with the increasing doses of lipitor . Conclusions Lipitor can effectively improve the cerebral hemodynamic status and ease carotid atherosclerosis of patients with cerebral infarction, and its therapeutic effect increases with the increasing doses of lipitor.关键词
立普妥/脑梗死/脑血流/粥样斑块Key words
Lipitor/Cerebral infarction/Cerebral blood flow/Atherosclerotic plaque分类
医药卫生
