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高效液相色谱法测定氯雷他定片含量

赵云鹏 耿倩 王建明

医学信息Issue(14):361-362,2.
医学信息Issue(14):361-362,2.

高效液相色谱法测定氯雷他定片含量

Determination the Assay of Loratadine Tablets by HPLC

赵云鹏 1耿倩 1王建明1

作者信息

  • 1. 石药集团欧意药业有限公司,河北 石家庄 050051
  • 折叠

摘要

Abstract

To establish a method for determination the assay of Loratadine Tablets, use HPLC with the column of L7,4.6×150mm,5?m;0.01 M Dibasic potassium phosphate-methanol-acetonitrile (7:6:6) , Adjust with 10% phosphoric acid solution to an apparent pH of 7.2 as Mobile phase;and 254nm as detection wavelength.Use external standard method to calculate the assay of Loratadine Tablets. Peak area and concentration presents good linearity in experimental range, the correlation coef icient is 0.9998, the average recovery is 100.4%(n=9),RSD is 0.9%.The method has a good specificity, reproducibility, accurancy and high sensitivity, can use to determination the assay of Loratadine Tablets.

关键词

高效液相色谱法/氯雷他定片/含量

Key words

HPLC/Loratadine Tablets/Assay

引用本文复制引用

赵云鹏,耿倩,王建明..高效液相色谱法测定氯雷他定片含量[J].医学信息,2013,(14):361-362,2.

医学信息

1006-1959

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