摘要
Abstract
Objective:To investigate the ef ective rate and arrest of bone marrow (decrease of leucocytes, plate-let) ofneoadjuvant chemotherapy schemes NP and GP in the therapy of advanced non- smal cel lung cancer by Meta analysis. Methods:After general y col ection the clinical literatures published in domestic and overseas from1994 to 2005 that reported on the ef ective rate and arrestofbonemarro (decrease of leukocyte, platelet) ofneoad-juvant chemotherapy schemesNP andGP in the therapy ofadvanced non-smal cel lung cancer, Meta analysiswas performed are processed by Review Manager 4. 2 program, selecting fixed or random modelbased on the heterogeneity test. Results:1From 1994 to 2005 a total of 12 studies were selected, the experimental group 413 cases. A total of 401 cases of the control group. The results show:The ef ective RR was 1.05, 95%CI 0.90-1.23, test for overal ef ect Z=0. 63, P>0. 05, no statistical y significant;leukopenia RR value of 1.43, 95%CI 1.26-1.61, test for overal ef ect Z=5. 58, P<0. 05, there was significant;thrombocytopenia RR was 0.83, 95%CI 0.72~0.96, test for overal ef ect Z=2. 44, P<0. 05, was statistical y significant. Conclusion:NP and GP schemes are ef ective in therapy ofnon- smal cel lung cancer.Decrease of leukocyte and platelet are two adverse ef ects. Decrease of leukocyte is greater in NP schemes, decrease of platelet is greater in GP schemes.关键词
NP方案/GP方案/晚期非小细胞肺癌/Meta分析Key words
NP schemes/GP schemes/Adcvanced non-smal cel lung cancer/Meta analysis分类
医药卫生
