摘要
Abstract
Objective To study the the type of the medicine for al ergy induced by anti-tuberculosis drugs, and categories sequences of the sensitized drugs that induced drug eruptions, clinical features, consequences. Methods 85 patients with tuberculosis treated in the fourth hospital of Lianyungang from January 2013 to April 2015 who occur skin rashes after receiving anti-tuberculosis treatment. To study the the type of the medicine for al ergy, categories sequences of the sensitized drugs, clinical features and consequences. Results 17 patients can not be clearly induced drug hypersensitivity due to various reasons. 68 people in 89 cases ultimately defined by sensitive drugs, fol owed by rifampicin (RFP) in 28 cases, ethambutol hydrochloride (EMB) in 19 cases, pyrazinamide (PZA) in 15 cases, rifapentine (RFT) in 9 cases, 7 cases of isoniazid (INH), pasiniazid (DIP) in 4 cases, 3 cases of levofloxacin hydrochloride, 3 cases of gatifloxacin, protionamide 1 case. 10 cases were al ergic to ifampicin, but weren't al ergic to rifapentine. 1 cases was al ergic to both rifampin and rifapentine. There were dif erent types of skin rash, urticaria, erythema polymorphe, eczema eruption, scarlet rash, erythema polymorphe etc. Conclusion There were dif erent types of skin rash casued by anti-tuberculosis drugs. The incidence rates wre (from high to low) rifampicin, hydrochloride ethambutol, pyrazinamide, rifapentine, isoniazid, isoniazid aminosalicylate respectively. The cross al ergy of rifampin and rifapentine is less. The prognosis is excel ent after termimtion the anti-tuberculosis drugs and with anti-al ergic treatment.关键词
皮疹/抗结核药物/药疹类型/临床分析Key words
Durg eruption/Anti-tuberculosis/Type of the medicine for al ergy/Clinic analysis
