摘要
Abstract
Objective To investgate whether dexmedetomidine added to ropivacaine could safely prolong the duration of analgesia without adverse ef ects when compared with ropivacaine alone in patients after total knee arthroplasty (TKA).Methods We enrol ed 40 patients undergoing elective TKA under general anesthesia with femoral nerve block (FNB).Patients who were randomized into two groups with 20 cases in each group underwent ultrasound and nerve stimulator guided FNB using either 40ml 0.5%ropivacaine(R group) or 0.5%ropivacaine plus 150μg dexmedetomidine(DR group). The primary outcomes were self-reported duration of the nerve block ,analgesic consumption,pain score in rest and movement,the force of quadriceps femoris,activity of knee and complications after surgery.Results The wanning of sensory and motor block in DR group was 18h while it was 14h in R group ( =0.0015).The pain score at rest and activity at postoperative 8~14h in DR group were lower than in R group ( <0.05).No dif erences were found in the pain score at rest and activity at postoperative 4h,6h and 24h,opioids and other analgesics consumption during and after operation, activity of knee and force of quadriceps femoris in patients of both groups ( >0.05).Conclusion Dexmedetomidine added to ropivacaine for FNB increased duration of nerve block and improved postoperative pain.These benefits and results encourage further study in the ef icacy and safety of using dexmedetomidine in peripheral never block in humans.关键词
全膝关节置换术/股神经阻滞/术后镇痛/右美托咪定/罗哌卡因Key words
Total knee arthroplasty/Femoral nerve block/Postoperative analgesia/Dexmedetomidine/Ropivacaine
