医药导报Issue(10)：1373-1376,4.DOI:10.3870/j.issn.1004-0781.2015.10.030
湖北省汉族肿瘤患者CYP 2 C19∗2多态性分布频率∗
Genetic Polymorphism Analysis of Drug-metabolizing Enzyme CYP2C19*2 in Tumor Patients of Han Poputation from Hubei Province
摘要
Abstract
Objective To investigate the distribution frequency of allele genetic polymorphism of drug-metabolizing enzyme CYP2C19∗2 (rs4244285) in tumor patients of Han population from Hubei province,to provide guidance for clinical rational drug use related to the genetic polymorphism. Methods CYP2C19∗2 genotyping was performed by Fluorescence Dye Terminator Cycle Sequencing System in 285 cancer patients. Genotype frequency and allele frequency were calculated and the genotype distribution in different genders was compared. Compared with the previous studies, we clarified the frequencies of CYP2C19∗2 gene polymorphisms in different nationalities. Results All the 285 patients in this study were Han population. The genotype frequency of CYP2C19∗2 was 113 (39.6%),138 (48.4%) and 34 (11.9%) for wild-type homozygote (GG), heterozygote (GA) and variant homozygote (AA),respectively.The CYP2C19∗2 mutant allele frequency was 36.1%.Genotype distribution of male and female patients did not reach significant difference. Conclusion There is no difference in CYP2C19∗2 genotypes distribution among different ethnic groups.关键词
细胞色素 P 450酶/单核苷酸变异/基因多态性Key words
Cytochrome P 450/Single nucleotide polymorphism/Genetic polymorphisms分类
医药卫生引用本文复制引用
宋海斌,王虚实,陈思,张伟,陈元,褚倩..湖北省汉族肿瘤患者CYP 2 C19∗2多态性分布频率∗[J].医药导报,2015,(10):1373-1376,4.基金项目
湖北省自然科学基金(2013CFB138)；湖北省卫计委青年人才项目( WJ2015Q009)；湖北省卫生厅基金( JX5B37) （2013CFB138）
