摘要
Abstract
Objective This study is to discuss the effects on chronic heart failure (CHF) patients treated by atorvastatin calcium combined with trimetazidine.Methods 86 patients with CHF were randomly divided into two groups: control group (treated by conventional therapy) and treatment group (cured by atorvastatin calcium combined with trimetazidine, based on the conventional therapy). Then these indexes as follow were compared before therapies and after 24 weeks:left ventricular ejection fraction (LVEF), stroke volume (SV), left ventricular diameter (LVEDD), serum C-reactive protein (CRP), sodium plasma brain natriuretic peptide (BNP) and the distance of 6 minutes walking test.Results Compared with the previous treatment, after treatment each group improved significantly in LVEF, LVEDD and SV (P<0.05), and the leves of CRP and BNP were significantly decreased after treatment, and the distances of 6 minutes walking were extended. Furthermore, the BNP levels of treatment group cured by atorvastatin calcium combined with trimetazidine decreased significantly more than the control group (all P<0.05), and the distance of 6 minutes walking test were significantly longer (P<0.05).Conclusion On the basis of conventional, therapy plus atorvastatin calcium combined with trimetazidine may further reduce the CRP and BNP levels of patients with heart failure in blood. In addition, anti-inflammatory effects, myocardial oxygen consumption reducing and significantly improvement of patients' heart function were all act in therapy group. Significantly extend distance of the 6 minutes walking test were improved the exercise tolerance in patients.关键词
曲美他嗪/阿托伐他汀/心力衰竭Key words
trimetazidine/atorvastatin calcium/heart failure分类
医药卫生
