原子能科学技术Issue(11)：1932-1938,7.DOI:10.7538/yzk.2015.49.11.1932
新型SPECT/MRI双模态显像剂SPION-DMSA-RGD-99 Tcm的合成与生物评价
Synthesis and Biological Evaluation of SPECT/MRI Dual-modal Imaging Agent SPION-DMSA-RGD-99 Tcm
王晓 1崔海平 2史旭东 1梁积新 2孙钰林 1申一鸣 2沈浪涛1
作者信息
- 1. 中国原子能科学研究院 国家同位素工程技术研究中心，北京 102413
- 2. 原子高科股份有限公司，北京 102413
- 折叠
摘要
Abstract
In order to investigate the possibility of SPION-DMSA-RGD-99 Tcm as a SPECT/MRI dual-modal imaging agent, SPION-DMSA-RGD and its radiolabeled SPION-DMSA-RGD-99 Tcm were prepared.SPION-DMSA-RGD was prepared based on SPION-DMSA and c(RGDfC).SPION-DMSA-RGD was characterized by means of vari-ous methods.SPION-DMSA-RGD-99 Tcm was given by labeling with 99 Tcm .The biodis-tribution studies of SPION-DMSA-RGD-99 Tcm in normal mice and the nude mice bearing U87MG human glioma were performed.The MRI and SPECT imaging of SPION-DMSA-RGD and SPION-DMSA-RGD-99 Tcm in the nude mice bearing U87MG human glioma were carried out,respectively.The results show that SPION-DMSA-RGD ex-hibits super-magnetic properties.The labeling yield of SPION-DMSA-RGD with 99 Tcm is about 98%.SPION-DMSA-RGD-99 Tcm displays fast clearance from the blood and high accumulation in the liver.The tumor uptake of SPION-DMSA-RGD-99 Tcm is higher than that of SPION-DMSA-99 Tcm .The MRI and SPECT images show that the tumor active targeting of SPION-DMSA-RGD and SPION-DMSA-RGD-99 Tcm are obvious. Therefore,SPION-DMSA-RGD-99 Tcm can be acting as a SPECT/MRI dual-modal ima-ging agent for nude mice bearing U87MG human glioma.关键词
超顺磁氧化铁纳米颗粒/二巯基丁二酸/c(RGDfC)/99 Tcm/SPECT/MRI双模态显像剂Key words
super-magnetic iron oxide nanoparticle/DMSA/c(RGDfC)/99 Tcm/SPECT/MRI dual-modal imaging agent分类
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王晓,崔海平,史旭东,梁积新,孙钰林,申一鸣,沈浪涛..新型SPECT/MRI双模态显像剂SPION-DMSA-RGD-99 Tcm的合成与生物评价[J].原子能科学技术,2015,(11):1932-1938,7.
