自动化学报2015，Vol.41Issue(11)：1893-1900,8.DOI:10.16383/j.aas.2015.c150211
动态加权蛋白质相互作用网络构建及其应用研究
Construction of Dynamic-weighted Protein Interactome Network and Its Application
摘要
Abstract
A protein would interact with different proteins under different conditions or at different time instants, which is the dynamic attribute of interactions. Proteins participate in different functional modules in different stages of molecular processing to perform different functions with other proteins. So, research of dynamic protein-protein interaction would contribute to the accuracy improvement of protein functions prediction. We construct a dynamic protein interaction network (D-PIN) by integrating protein-protein interaction network and time course gene expression data. To reduce the negative effect of false "negative" on the protein function prediction, we predict and generate some new protein interactions which combine with proteins' domain information and protein complexes information and weight all the interactions. Based on the weighted dynamic network, we propose a method for predicting protein function, named D-PIN. Experimental results compared with using three different yeast interactome networks indicate that the comprehensive performance of D-PIN is 14% higher other competing methods. Results also verify the effectiveness of the constructed dynamic-weighted protein interactome network.关键词
动态加权网络/功能预测/蛋白质相互作用网络/基因表达Key words
Dynamic weighted network/functions prediction/protein interactome network/gene expression引用本文复制引用
胡赛,熊慧军,赵碧海,李学勇,王晶..动态加权蛋白质相互作用网络构建及其应用研究[J].自动化学报,2015,41(11):1893-1900,8.基金项目
国家自然科学基金(11501054),湖南省自然科学基金项目(13JJ4106, 14JJ3138), 湖南省教育厅项目(10C0408, 15C0124), 湖南省科技计划项目(2010FJ3044, 2015GK3072) 资助Supported by National Natural Science Foundation of China (11501054), Natural Science Foundation of Hunan Province (13JJ4106, 14JJ3138), National Scientific Research Founda-tion of Hunan Province (10C0408, 15C0124), and Science and Technology Plan Project of Hunan Province (2010FJ3044, 2015GK3072) （11501054）
