中国病理生理杂志Issue(11)：2101-2106,6.DOI:10.3969/j.issn.1000-4718.2015.11.029
长链非编码 RNA 对心脏发育的表观遗传学调控研究进展
Progress on epigenetic regulation of long noncoding RNAs in cardiac development and heart diseases
摘要
Abstract
It was previously revealed that noncoding RNAs, especially microRNAs, control cardiac genes and regulate heart function.Recently, growing evidence from high-throughput genomic platforms has confirmed that long non-coding RNAs ( lncRNAs) serve as new and enigmatic regulators in cardiac development and homeostasis.Nevertheless, lit-tle is known about their characteristics compared to microRNAs.Here, we review the latest progress on lncRNAs in cardiac biology and diseases, summarizing detailed knowledge of their functions and novel cardiac-related gene regulatory mecha-nisms in epigenetic processes.Finally, we highlight that lncRNAs could be promising therapeutic targets and diagnostic bi-omarkers in cardiac pathophysiology.关键词
长链非编码RNA/心脏发育/心脏疾病/表观遗传学Key words
Long noncoding RNAs/Cardiac development/Heart diseases/Epigenetics分类
医药卫生引用本文复制引用
杨翔宇,余细勇..长链非编码 RNA 对心脏发育的表观遗传学调控研究进展[J].中国病理生理杂志,2015,(11):2101-2106,6.基金项目
国家自然科学基金资助项目（ No．81330007；No．81120108003）；广东省科技计划国际合作项目 （）
