中国病理生理杂志Issue(11)：2107-2112,6.DOI:10.3969/j.issn.1000-4718.2015.11.030
长链非编码 RNAs 的生物功能及其与器官发育和恶性肿瘤的关系
Long noncoding RNAs:biological functions and applications in organ development and malignant tumors
摘要
Abstract
Long noncoding RNAs( lncRNAs) are classified as transcripts >200 nucleotides in length with lit-tle or no evidence of protein-coding potential, and can regulate gene expression at various levels, including transcriptional regulation, posttranscriptional processing and so on.It has been widely involved in cell differentiation, individual develop-ment and other important life processes.Recent studies show lncRNA-related dysfunction plays critical roles in various dis-eases, indicating that lncRNA may serve as a new target for disease diagnosis and treatment.This review summarizes the functions of lncRNAs, including various modes of lncRNAs in regulating gene expression, the roles of lncRNAs in differen-tiation and development, and the connection between lncRNAs and malignant tumor.关键词
长链非编码RNAs/恶性肿瘤Key words
Long noncoding RNAs/Malignant tumor分类
医药卫生引用本文复制引用
张明娇,吴勇,李珉珉..长链非编码 RNAs 的生物功能及其与器官发育和恶性肿瘤的关系[J].中国病理生理杂志,2015,(11):2107-2112,6.基金项目
广东省医学科研基金资助项目 （）
