中国当代儿科杂志Issue(10)：1093-1097,5.DOI:10.7499/j.issn.1008-8830.2015.10.015
下丘脑-垂体-性腺轴抑制程度对中枢性性早熟女童成年预测身高的影响
Effects of HPGA suppression on predicted adult height in girls with central precocious puberty
陶月红 1曾碧荷 1沙里夫1
作者信息
- 1. 江苏省苏北人民医院儿科，江苏 扬州 225001
- 折叠
摘要
Abstract
ObjectiveTo study the relationship between the suppression of the hypothalamic-pituitary-gonadal axis (HPGA) and the predicted adult height (PAH) in girls with central precocious puberty (CPP) during the treatment with gonadotropin-releasing hormone analogue (GnRHa), in order to provide guidance for individualized GnRHa dose adjustment in clinical practice.MethodsThe clinical data of 75 CPP girls were collected, and then height, bone age (BA), uterine and ovarian volumes, and peak luteinizing hormone (LH), peak follicle-stimulating hormone (FSH), and estradiol (E2) levels were recorded at different time points of GnRHa treatment. PAH at each time point was calculated. PAH improvement (ΔPAH=PAH-target height) and its relationship with the degree of HPGA suppression were analyzed. Threshold effect analysis was applied to determine the best HPGA suppression range forΔPAH.ResultsAfter GnRHa treatment, PAHs were improved markedly compared with the data in the early stage of treatment. ΔPAH showed a negative correlation with ΔBA. At 24 months of treatment, ΔPAH was also negatively correlated with LH. Uterine volume controlled between 2.3 and 3.0 mL, LH level controlled below 0.8 IU/L, and FSH controlled below 2.4 IU/L could slow down the growth of BA and improve PAH.ConclusionsGnRHa treatment can improve the PAH of CPP girls. Selection of an appropriate therapeutic dose for GnRHa to control uterine volume, LH and FSH levels within certain ranges can slow down the growth of BA and improve PAH.关键词
促性腺激素释放激素类似物/中枢性性早熟/下丘脑-垂体-性腺轴/成年预测身高/儿童Key words
Gonadotropin-releasing hormone analogue/Central precocious puberty/Hypothalamic-pituitary-gonadal axis/Predicted adult height/Child引用本文复制引用
陶月红,曾碧荷,沙里夫..下丘脑-垂体-性腺轴抑制程度对中枢性性早熟女童成年预测身高的影响[J].中国当代儿科杂志,2015,(10):1093-1097,5.
