中国当代儿科杂志Issue(10)：1107-1111,5.DOI:10.7499/j.issn.1008-8830.2015.10.018
FGF23基因多态性与川崎病及其冠状动脉损伤的相关性
Association of FGF23 gene polymorphism with Kawasaki disease and coronary artery lesions
耿亚楠 1张宏艳2
作者信息
- 1. 天津医科大学研究生院，天津 300070
- 2. 天津市儿童医院，天津 300074
- 折叠
摘要
Abstract
ObjectiveTo study the distribution of polymorphism of c.212-37insC (rs3832879) in intron 1 of ifbroblast growth factor 23 (FGF23) gene and its association with Kawasaki disease (KD) and coronary artery lesions (CAL).MethodsForty children with KD were enrolled in this study, among whom 16 children had concurrent CAL. Twenty-six age-matched healthy children were enrolled as controls. PCR andgene sequencing were applied to explore the distribution of polymorphism of c.212-37insC (rs3832879) in FGF23 gene in KD patients and controls.Results Among 40 children with KD, 14 (35%) carried the polymorphism of c.212-37insC (rs3832879) in FGF23 gene; among 26 controls, 6 (23%) carried such polymorphism. There was no signiifcant difference in genotype distribution at this locus between the two groups (P=0.30). Among 16 children with CAL, 9 (56%) carried the polymorphism at this locus;among 24 children without CAL, 5 (21%) carried such polymorphism. As for the comparison of two subgroups with and without CAL, the difference in genotype distribution at this locus had statistical signiifcance (P=0.02,OR=4.89, 95%CI:1.21-19.71).ConclusionsThe polymorphism of c.212-37insC (rs3832879) in FGF23 gene may not be associated with the pathogenesis of childhood KD, but it may be associated with the development of CAL in children with KD.关键词
川崎病/成纤维细胞生长因子23/单核苷酸多态性/冠状动脉损伤/儿童Key words
Kawasaki disease/Fibroblast growth factor 23/Single-nucleotide polymorphism/Coronary artery lesion/Child引用本文复制引用
耿亚楠,张宏艳..FGF23基因多态性与川崎病及其冠状动脉损伤的相关性[J].中国当代儿科杂志,2015,(10):1107-1111,5.
