中国当代儿科杂志Issue(10)：1112-1118,7.DOI:10.7499/j.issn.1008-8830.2015.10.019
CYP1A1*2A多态性与儿童急性淋巴细胞白血病易感性的Meta分析
Association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia：a Meta analysis
摘要
Abstract
ObjectiveTo explore the association between CYP1A1*2A polymorphism and susceptibility to childhood acute lymphoblastic leukemia (ALL) through a Meta analysis.MethodsInclusion and exclusion criteria were formulated and English and Chinese databases (PubMed, OVID Database, CBM, CNKI, and Wanfang Data) were searched comprehensively. The studies (from January 1999 to April 2015) related to the association between CYP1A1*2A polymorphism and susceptibility to childhood ALL were collected. STATA 12.0 Software was applied to perform the Meta analysis for the articles included.ResultsA total of 12 articles were included for analysis (11 English articles and 1 Chinese article), which involved 3 355 cases in total. The results of the Meta analysis showed a signiifcant association between CYP1A1*2A polymorphism and susceptibility to childhood ALL (allele model:OR=1.31, 95%CI:1.07-1.61; dominant model:OR=1.33, 95%CI: 1.13-1.56; codominant model:OR=1.30, 95%CI: 1.10-1.54). According to the results of a subgroup analysis based on ethnic origin, an increased risk of childhood ALL was observed in both Asian subgroup (dominant model:OR=1.57, 95%CI: 1.19-2.08; codominant model:OR=1.61, 95%CI: 1.20-2.17) and the Caucasian subgroup (allele model:OR=1.31, 95%CI: 1.04-1.63; dominant model:OR=1.22, 95%CI: 1.00-1.49). ConclusionsCYP1A1*2A polymorphism may be associated with the genetic susceptibility to childhood ALL.关键词
急性淋巴细胞白血病/易感性/基因多态性/Meta分析/儿童Key words
Acute lymphoblastic leukemia/Susceptibility/Polymorphism/Meta analysis/Child引用本文复制引用
邹泽巧,岳丽杰,任艳飞..CYP1A1*2A多态性与儿童急性淋巴细胞白血病易感性的Meta分析[J].中国当代儿科杂志,2015,(10):1112-1118,7.基金项目
国家自然科学基金资助项目（30471830）；深圳市科技计划重点项目（201101011）。 （）
