中国当代儿科杂志Issue(11)：1200-1203,4.DOI:10.7499/j.issn.1008-8830.2015.11.010
粘附分子CD62P和CD44在毛细支气管炎患儿外周血中的表达及意义
Expression and significance of adhesion molecules CD62P and CD44 in peripheral blood of infants with bronchiolitis
邹丽萍 1王伟 1张艳丽 1张艳 1王莉1
作者信息
- 1. 郑州大学第三附属医院儿内科，河南 郑州 450052
- 折叠
摘要
Abstract
ObjectiveTo explore the expression and signiifcance of the adhesion molecules CD62P and CD44 in the peripheral blood of infants with bronchiolitis.MethodsThirty-three infants with bronchiolitis in the acute phase and 19 infants with bronchiolitis in the recovery phase, who were hospitalized between November 2014 and May 2015, were enrolled. Thirty infants with bronchopneumonia and 26 infants without infection were enrolled as the bronchopneumonia group and the control group, respectively. The CD62P expression in the peripheral blood of each group was measured by lfow cytometry, and the CD44 level in serum was determined using ELISA.ResultsThe levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the acute phase were signiifcantly higher than those in the bronchiolitis group in the recovery phase, the bronchopneumonia group, and the control group (P<0.05). The levels of the adhesion molecules CD62P and CD44 in the bronchiolitis group in the recovery phase were also signiifcantly higher than those in the control group (P<0.05). In the bronchiolitis group in the acute phase, there was a positive correlation between CD62P expression and serum CD44 level (r=0.91;P<0.05).ConclusionsThe adhesion molecules CD62P and CD44 play an important role in the pathogenesis of bronchiolitis, and their levels can relfect the severity of inlfammatory response in infants with bronchiolitis.关键词
毛细支气管炎/黏附分子/CD62P/CD44/儿童Key words
Bronchiolitis/Adhesion molecule/CD62P/CD44/Infant引用本文复制引用
邹丽萍,王伟,张艳丽,张艳,王莉..粘附分子CD62P和CD44在毛细支气管炎患儿外周血中的表达及意义[J].中国当代儿科杂志,2015,(11):1200-1203,4.
