中国感染控制杂志Issue(10)：672-675,4.DOI:10.3969/j.issn.1671-9638.2015.10.006
血液病合并侵袭性真菌感染病原学及危险因素
Pathogenic features and risk factors of invasive fungal infection in patients with hematopathy
王凡 1韩志海 1孟激光 1李泳群 1陈韦 1赵春亭2
作者信息
- 1. 海军总医院，北京 100048
- 2. 青岛大学附属医院，山东 青岛 266000
- 折叠
摘要
Abstract
Objective To investigate the status of invasive fungal infection(IFI)associated with hematopathy,and evaluate drug resistance and risk factors of fungal infection.Methods 1 246 cases of infection occurred in patients in a hospital from 2006 to 2010 were analyzed retrospectively,pathogenic features and risk factors of IFI were ana-lyzed.Results There were 281 cases of fungal infection,and 162 fungal isolates were isolated,the main infection site was respiratory tract(134 isolates,82.72%).Four major Candida were Candida albicans ,Candida tropicalis , Candida glabrata ,and Candida krusei ;in 2006-2009,the main fungi were Candida albicans ,while in 2010,the majority were non-Candida albicans .The resistant rates of four isolated Candida to fluconazole and itraconazole were 5.15% and 4.41 % respectively,6 isolated Candida krusei strains were all resistant to both fluconazole and itraconazole,voriconazole-resistant strain was not found.The independent risk factors for fungal infection were dia-betes and duration time of agranulocytosis>14 days.Conclusion The proportion of infection caused by non-Candi-da albicans increased obviously,fluconazole-and itraconazole-resistant non-Candida albicans strains have emerged, comprehensive measures should be adopted to prevent IFI actively and treat patients early.关键词
血液病/感染/病原菌/侵袭性真菌感染/抗药性,微生物/危险因素Key words
hematopathy/infection/pathogen/invasive fungal infection/drug resistance,microbial/risk factor分类
医药卫生引用本文复制引用
王凡,韩志海,孟激光,李泳群,陈韦,赵春亭..血液病合并侵袭性真菌感染病原学及危险因素[J].中国感染控制杂志,2015,(10):672-675,4.
