中国感染控制杂志Issue(11)：772-775,4.DOI:10.3969/j.issn.1671-9638.2015.11.014
重症监护病房患者洋葱伯克霍尔德菌感染临床特点及耐药性
Clinical characteristics and antimicrobial resistance of Burkholderia cepa-cia causing infection in intensive care unit patients
南玲 1刘丁 1王豪 1陈萍 1李茂圆 1黄庆宁 1方清永 1成瑶1
作者信息
- 1. 第三军医大学第三附属医院野战外科研究所，重庆 400042
- 折叠
摘要
Abstract
Objective To understand the specimen sources,clinical characteristics,and antimicrobial resistance of Burkholderia cepacia (B .cepacia )isolated from infected patients in intensive care unit(ICU),so as to provide reference for guiding rational use of antimicrobial agents.Methods Clinical data of patients with B .cepacia infec-tion in an ICU between 2011 and 2014 were analyzed retrospectively,antimicrobial resistance of strains was ana-lyzed.Results A total of 267 B .cepacia strains were isolated,the major specimen sources were sputum (80.15%, n=214),blood(14.23%,n =38),and urine(3.37%,n =9).Antimicrobial susceptibility testing results revealed that B .cepacia had multiple resistance,and was naturally resistant to multiple clinically used antimicrobial agents, such as ampicillin,cefazolin,ampicillin/sulbactam,nitrofurantoin,and cefuroxime,resistant rates were all 100%;resistant rates to ceftazidime and levofloxacin were 4.12% and 3.00% respectively;resistant rate to compound sulfa-methoxazole had increased tendency(χ2 =5.885,P =0.015).Conclusion Isolation of B .cepacia in ICU increased year by year,antimicrobial resistance is serious,management and targeted monitoring of prevention and control of healthcare-associated infection should be strengthened,antimicrobial agents should be chosen according to antimi-crobial susceptibility testing results.关键词
重症监护病房/洋葱伯克霍尔德菌/临床特点/抗药性,微生物/合理用药Key words
intensive care unit/Burkholderia cepacia/clinical characteristic/drug resistance,microbial/rational drug use分类
医药卫生引用本文复制引用
南玲,刘丁,王豪,陈萍,李茂圆,黄庆宁,方清永,成瑶..重症监护病房患者洋葱伯克霍尔德菌感染临床特点及耐药性[J].中国感染控制杂志,2015,(11):772-775,4.
