中国康复理论与实践Issue(2)：132-135,4.DOI:10.3969/j.issn.1006-9771.2013.02.009
番茄红素抗氧化应激效应对大鼠脊髓损伤后运动功能恢复的影响①
Anti-oxidative Stress Effect of Lycopene on Motor Function after Spinal Cord Injury in Rats
摘要
Abstract
Objective To observe the influence of anti-oxidative stress effect of lycopene (LP) on motor function after spinal cord injury (SCI) in rats. Methods 36 healthy adult Sprague-Dawley rats were randomly divided into Groups A, B and C with 12 rats in each group. SCI model was made by Allen's mode (10 g×25 mm) on T9. Group A received no treatment, 30 mg/kg methylprednisolone sodium succinate was injected for Group B in peritoneal cavity 30 min after SCI, 20 mg/kg LP was given orally for Group C. On the 1st d, 3rd d and 7th d af-ter operation, the motor function was assessed by slanting board test and Basso-Beattie-Bresnahan scale (BBB); superoxide dismutase (SOD) and malondialdehyde (MDA) were determined in serum. Results Compared with Group A, the scores of the slanting board test signif-icantly increased in Group C 1 d, 3 d, and in Group B 1 d, 3 d and 7 d after operation (P<0.05); the BBB scores significantly increased in Group C 1 d, 3 d and 7 d, and in Group B 1 d, 7 d after operation (P<0.05); the activity of SOD significantly increased in Group C 1 d, 3 d and 7 d, and in Group B 3 d, 7 d after operation (P<0.05); the content of MDA significantly decreased in Group C 3 d, 7 d, and in Group B 1 d, 7 d after operation (P<0.05). Conclusion Lycopene can reduce the level of oxidative stress and promote the motor function in rats after acute SCI.关键词
番茄红素/脊髓损伤/丙二醛/超氧化物歧化酶/运动功能Key words
lycopene/spinal cord injury/malondialdehyde/superoxide dismutase/motor function分类
医药卫生引用本文复制引用
李晓,卓睿,李亚光,罗晨禹,杨拯,谢少华,张尧,杨海燕,马延仃,张艺,胡雯思..番茄红素抗氧化应激效应对大鼠脊髓损伤后运动功能恢复的影响①[J].中国康复理论与实践,2013,(2):132-135,4.基金项目
成都医学院创新性实验项目基金(No. CX201219)。 （No. CX201219）
