中国康复理论与实践Issue(5)：436-439,4.DOI:10.3969/j.issn.1006-9771.2013.05.010
早期干预对宫内感染致脑损伤仔鼠脑组织NB-3表达的影响①
Effect of Early Intervention on Expression of NB-3 in Neonatal Rats with Cerebral Injury Induced with Intrauterine Infection
袁新华 1王红丽 1邓庆先1
作者信息
- 1. 湖州市妇幼保健院儿科，浙江湖州市313000
- 折叠
摘要
Abstract
Objective To investigate the effect of early intervention on adhesion molecule NB-3 expressing in cerebral injured neonatal rat induced with intrauterine infection. Methods Pregnant rats were consecutively injected with lipopolysaccharide (LPS) 380 μg/kg or sa-line 17 d after gestation. The offspring from the LPS group accepted early intervention (I group, n=40) or not (NI group, n=40), and those for saline group were as control group (n=40). They were assessed with suspension test 14 d and 28 d after born, and the expression of were NB-3 were detected with immunohistochemistry 1 d, 7 d, 14 d, 21 d, 28 d after born. Results The expression of NB-3 was different among these 3 groups, as well as the scores of suspension test (P<0.001). Conclusion Intrauterine infection increases the expression of NB-3 of neo-natal rats with brain damage. The early intervention may increase persistently the expression of NB-3, and improve the motor function.关键词
宫内感染/脑损伤/早期干预/NB-3/神经可塑性/大鼠Key words
intrauterine infection/cerebral injury/early intervention/NB-3/neuronal plasticity/rats分类
医药卫生引用本文复制引用
袁新华,王红丽,邓庆先..早期干预对宫内感染致脑损伤仔鼠脑组织NB-3表达的影响①[J].中国康复理论与实践,2013,(5):436-439,4.
