中国康复理论与实践Issue(7)：628-630,3.DOI:10.3969/j.issn.1006-9771.2013.07.009
咯利普兰治疗大鼠脊髓横断损伤的实验研究
Effects of Rolipram on Spinal Cord Transection Injury in Rats
李锋涛 1程斌 2李浩鹏 1臧全金 1张廷 1贺西京1
作者信息
- 1. 西安交通大学第二附属医院，骨二科，陕西西安市710004
- 2. 西安交通大学第二附属医院，骨三科，陕西西安市710004
- 折叠
摘要
Abstract
Objective To investigate the possibility of rolipram for treatment of spinal cord injury (SCI) in rats. Methods 30 adult fe-male Sprague-Dawley rats were divided into sham-operation group (sham group, n=10), spinal cord injury group (SCI group, n=10) and ro-lipram treatment group (R group, n=10). The rats in SCI group and R group were modeled as spinal cord transection injury, and R group was administrated with rolipram subcutaneouly after SCI. They were assessed with Basso Beattie and Bresnahan (BBB) score 2, 4, 6, and 8 weeks after SCI, and the expressions of growth associated protein 43 (GAP-43) and glial fibrillary acidic protein (GFAP) were detected with immunohistochemistry 2 weeks after SCI. Results There were significant difference in the BBB scores between SCI and R groups 6 and 8 weeks after SCI (P<0.05). The expression of GAP-43 was more and GFAP was less in R group than in SCI group (P<0.05). Conclusion Ro-lipram can increase the expression of GAP-43 and inhibit the expression of GFAP, while improves the the motor function in rats after spinal cord transsection injury.关键词
脊髓损伤/咯利普兰/运动功能/生长相关蛋白43/胶质细胞酸性蛋白/大鼠Key words
spinal cord injury/rolipram/motor function/growth associated protein 43/glial fibrillary acidic protein/rats分类
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李锋涛,程斌,李浩鹏,臧全金,张廷,贺西京..咯利普兰治疗大鼠脊髓横断损伤的实验研究[J].中国康复理论与实践,2013,(7):628-630,3.
