中国康复理论与实践Issue(8)：729-733,5.DOI:10.3969/j.issn.1006-9771.2013.08.005
丁基苯酞对弥漫性脑创伤大鼠运动功能及学习记忆能力的影响①
Effects of 3-n-Butylphthalide on Neuromotor Function and Learning-Memory Function after Severe Diffuse Brain Injury in Rats
摘要
Abstract
Objective To study the effects of 3-n-butylphthalide (NBP) on motor function and learning and memory ability in rats with diffuse brain injury (DBI). Methods 128 male Sprague-Dawley rats were randomly divided into sham operation group, traumatic group, low-dose NBP treatment group and high-dose NBP treatment group with 32 rats in each group. Every group was divided into 24 h, 48 h and 72 h subgroups. DBI rat model was established according to the description of Marmarou's diffused brain injury. The histopathologic chang-es of cerebral tissue (0.2 cm bilateralis coronal line) were observed by light and electron microscope at 24 h, 48 h and 72 h after injury. Mor-ris water maze and rolling test were performed daily at 24, 48 and 72 h (time points). Results Compared with the model group, the damage of brain tissue decreased, and the survival nerve cells increased (P<0.01). The behavioral tests showed that the latency to find the platform shortened (P<0.01) and the frequency of crossing the platform increased in the 72 h subgroup (P<0.01). The general movement ability en-hanced in NBP groups (P<0.05). All the indexes were more significant in high-dose NBP treatment group. Conclusion NBP can improve neurological function and learning and memory function after brain injury and the molecular mechanisms is related to the decrease of the nerve cells lose and traumatic cerebral ultrastructure damage.关键词
弥漫性脑创伤/学习/运动/超微结构/大鼠Key words
diffuse brain injury/learning/motor/ultrastructure/rats分类
医药卫生引用本文复制引用
李建民,赵雅宁,薛承景,陈长香,李淑杏..丁基苯酞对弥漫性脑创伤大鼠运动功能及学习记忆能力的影响①[J].中国康复理论与实践,2013,(8):729-733,5.基金项目
1.河北省科技厅支撑课题(No.20276102D)；2.河北省教育厅重点课题(No. ZD2010106)。 （No.20276102D）
