中国康复理论与实践Issue(10)：1128-1132,5.DOI:10.3969/j.issn.1006-9771.2015.10.003
重复经颅磁刺激对脑梗死后轻度认知功能障碍的影响及安全性研究
Effects of Repetitive Transcranial Magnetic Stimulation on Cognitive Ability in Patients with Mild Cognitive Im-pairment after Ischemic Stroke
摘要
Abstract
Objective To explore the effects of repetitive transcranial magnetic stimulation (rTMS) on cognitive ability of patients after ischemic stroke. Methods 45 patients with mild cognitive impairment (MCI) after ischemic stroke were randomly assigned into control group (n=22) and observation group (n=23). Both groups received routine drugs and cognitive training. The observation group received rT-MS over the left dorsolateral prefrontal cortex (DLPFC) (5 Hz, 80%motor threshold) in addition for 4 weeks. Results The score of Montre-al Cognitive Assessment (MoCA), P300 latencies and amplitudes improved after treatment in both groups (P<0.001), and were better in the observation group than in the control group (P<0.05). The MoCA score was negatively related with P300 latency (r=-0.851, P<0.05). There was no severe adverse effect during the treatment. Conclusion rTMS could improve the cognitive ability of patients with MCI after stroke, with little side effect.关键词
脑梗死/轻度认知功能障碍/重复经颅磁刺激/事件相关电位/P300Key words
cerebral infarction/mild cognitive impairment/repetitive transcranial magnetic stimulation/event-related potential/P300分类
医药卫生引用本文复制引用
李亚梅,徐丽,杨艳,田金艳,余茜..重复经颅磁刺激对脑梗死后轻度认知功能障碍的影响及安全性研究[J].中国康复理论与实践,2015,(10):1128-1132,5.基金项目
1.四川省科技支撑项目(No.2014B064)；2.四川省中医管理局支撑项目(No.2014JY0032)。 （No.2014B064）
