中国康复理论与实践Issue(11)：1256-1259,4.DOI:10.3969/j.issn.1006-9771.2015.11.004
急性脑梗死患者外周血清巨噬细胞移动抑制因子、基质金属蛋白酶-9和超敏C-反应蛋白水平与病情严重程度的关系
Relationship of Serum Macrophage Migration Inhibitory Factor, Matrix Metalloproteinase-9 and Hypersensitive C-Reactive Protein with Severity of Acute Cerebral Infarction
摘要
Abstract
Objective To investigate the relationship of serum levels of macrophage migration inhibitory factor (MIF), matrix metallo-proteinase-9 (MMP-9), hypersensitive C-reactive protein (hs-CRP) with the severity of acute cerebral infarction (ACI). Methods 101 pa-tients with ACI were envolved and divided into 3 groups according to the scores of National Institute of Health Stroke Scale (NIHSS):mild group (group A, n=38, NIHSS score<4), moderate group (group B, n=36, NIHSS score 4-15) and severe group (group C, n=27, NIHSS score>15). Meanwhile, 44 non-ACI inpatients with atherosclerosis were included as control group (group D). Their serum MIF and MMP-9 were detected with ELISA, and hs-CRP with immunoturbidimety. Results The levels of serum MIF, MMP-9 and hs-CRP ranged from more to less as groups C, B, A and D (P<0.05). There was positive correlation of MIF with MMP-9 (r=0.301, P<0.01) and hs-CRP (r=0.309, P<0.001). Conclusion Serum MIF, MMP-9 and hs-CRP levels increased with the severity in ACI patients, which may be prediction of athero-sclerotic plaque instability.关键词
急性脑梗死/动脉粥样硬化/巨噬细胞移动抑制因子/基质金属蛋白酶-9/超敏C-反应蛋白/美国国立卫生研究院卒中量表Key words
acute cerebral infarction/atherosclerosis/macrophage migration inhibitory factor/matrix metalloproteinase-9/hypersensi-tive C-reactive protein/National Institute of Health Stroke Scale分类
医药卫生引用本文复制引用
于治华,王君,樊建华,高红华,高连波..急性脑梗死患者外周血清巨噬细胞移动抑制因子、基质金属蛋白酶-9和超敏C-反应蛋白水平与病情严重程度的关系[J].中国康复理论与实践,2015,(11):1256-1259,4.基金项目
国家自然科学基金面上项目(No.81471198)。 （No.81471198）
