摘要
Abstract
Objective To evaluate the clinical efficacy and safety of cyclosporine A combined with glucocorticoid in the treatment of immuno-globulin A ( IgA ) nephropathy with large number of protein urine . Methods Fifty-six patients with IgA nephropathy were randomly divid-ed into control group ( 28 cases ) and treatment group ( 28 cases ) . Methylprednisolone 0.8 mg· kg -1· d-1(maximum dose of 48 mg· d-1) was given to the control group , oral, twice a day, treated for 6 months. The treatment group was poured methylprednisolone at a starting dose of 0.5 mg· kg-1 · d -1 ( maximum dose 36 mg· d -1 ) , cyclosporine A with the initial dose of 100 mg· d-1 , less than 5 mg · kg -1 · d -1 , the con-centration of cyclosporine A was maintained at 100 -200 mg · mL-1 , and oral drug delivery , twice a day , the course of treatment was 6 months.Compared the clinical efficacy , renal function and adverse drug reactions rate between the two groups .Results After 24 weeks of treat-ment, the complete remission of treatment group (57.14%) was signifi-cantly higher than that of the control group (39.19%, P<0.05).After 2 weeks treatment , the urinary protein in treatment group (0.78+0.14 ) g was significantly lower than that in control group ( 1.08 +0.21 ) g (P<0.05).The incidence adverse drug reactions in two groups had no statistical difference ( P>0.05 ) .Conclusion Cyclosporine A combined with glucocorticoid of medium dose ( 0.5 mg· kg -1 · d-1 ) has better clinical efficacy and less adverse reactions on the treatment of IgA nephropathy , and is worth to recommend in clinical practice .关键词
IgA肾病/中等剂量/环孢素A/累积缓解率Key words
immunoglobulin A nephropathy/moderate dose/cyclosporine A/accumulative total remission rate分类
医药卫生
