中国临床药理学杂志Issue(18)：1863-1865,3.DOI:10.13699/j.cnki.1001-6821.2015.18.020
薏苡叶提取物对 H22荷瘤小鼠的体内抗肿瘤作用
Antitumor effect on H22 tumor - bearing mice of the extract from Coix lachryma-jobi L.leaves
摘要
Abstract
Objective To study the antitumor effect in vivo of Coix leaf′s water extract and alcohol extract of different concentrations on H 22 tumor-bearing mice.Methods Take 120 CL Kunming mice to prepare tumor models of cell transplantation , and divided these into 12 groups, with 10 mice in each group.There are model group and control group ( cy-clophosphamide , 20 mg · kg -1 ) , five difference concentration ( 0.15 , 0.30 ,0.45 ,0.60 ,0.75 g · mL -1 ) groups with Coix leaf′s water extract (CLWE) and alcohol extract(CLAE).The tumor of H22 tumor-bearing mice was weighed.The inhibitory rate, and calculate liver index, spleen index and thymus index were calculated .Results The best antitumor concentration of the extract from Coix leaf′s is 0.45 g· mL-1 .The inhi-bition rate of CLAE is better than the CLWE .Compared with the model group, the 0.45 g· mL-1 group of CLWE and each concentration groups of CLAE can significantly inhibit the growth of tumor ( P <0.05 , P<0.01 ) .The tumor inhibition rate of CLAE of 0.45 g · mL -1 reaches 63.2%.The Coix leaf′s extracts exert antitumor effect , and have a sig-nificant protective effect on thymus at the same time .Conclusion The best antitumor concentration of the extract from Coix leaf′s is 0.45 g· mL-1 .The inhibition rate of CLAE is better than that of the CLWE .关键词
薏苡叶提取物/H22荷瘤/体内抗肿瘤Key words
Coix leaf extract/H22 tumor/antitumor in vivo分类
医药卫生引用本文复制引用
李远辉,郭圣奇,黄挺章,马忠丽,黄莉莉,陆秋娜,李松波,黄锁义..薏苡叶提取物对 H22荷瘤小鼠的体内抗肿瘤作用[J].中国临床药理学杂志,2015,(18):1863-1865,3.基金项目
国家自然科学基金资助项目（81360684）；广西自然科学基金资助项目（2011GXNSFA018046）；广西中医药科技专项基金资助项目（ GZKZ 10-128）；广西中医药管理局课题基金资助项目（gzzc1047）；广西医学科学实验中心开放基金专项基金资助项目 （）
